γ,δ,ε-C(sp3)-H Functionalization through Directed Radical H-Abstraction

被引：109

作者：

Liu, Tao ^{[1
]}

Mei, Tian-Sheng ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 18期

关键词：

ALPHA-AMINO-ACIDS; PALLADIUM-CATALYZED ARYLATION; C(SP(3))-H BONDS; PHOTOCHEMICAL REACTION; ALKOXY RADICALS; ALKYLATION; LIGAND; OLEFINATION; ACTIVATION; SP(2);

D O I：

10.1021/jacs.5b02065

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aliphatic amides are selectively functionalized at the gamma- and delta-positions through directed radical 1,5 and 1,6 H-abstractions, respectively, The initially gamma- or delta-lactams are intercepted. by N-iodosuccinimide and trimethylsilyl azide, leading to double and triple C-H functionalizations at the gamma, delta-, and epsilon-positions. This new reactivity is exploited to convert alkyls into amino alcohols and allylic amines.

引用

页码：5871 / 5874

页数：4

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