Ex-vivo co-blockade of CD-155/TIGIT and PD-1/PD-L1 using CCAT-1, H19 and MALAT-1 LncRNAs in hepatocellular carcinoma

被引:3
|
作者
Youness, R. A. [1 ]
Gomaa, A. [2 ]
机构
[1] Univ Hertfordshire Hosted Global Acad Fdn, Sch Life & Med Sci, New Cairo, Egypt
[2] Natl Liver Inst, Hepatol Dept, Sheben Elkom, Egypt
关键词
D O I
10.1016/j.annonc.2021.10.147
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
128P
引用
收藏
页码:S1433 / S1433
页数:1
相关论文
共 40 条
  • [21] Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses
    Banta, Karl L.
    Xu, Xiaozheng
    Chitre, Avantika S.
    Au-Yeung, Amelia
    Takahashi, Chikara
    O'Gorman, William E.
    Wu, Thomas D.
    Mittman, Stephanie
    Cubas, Rafael
    Comps-Agrar, Laetitia
    Fulzele, Amit
    Bennett, Eric J.
    Grogan, Jane L.
    Hui, Enfu
    Chiang, Eugene Y.
    Mellman, Ira
    IMMUNITY, 2022, 55 (03) : 512 - +
  • [22] The blockade of PD-1/PD-L1 pathway promotes the apoptosis of CD19+CD25+ Bregs and suppresses the secretion of IL-10 in patients with allergic rhinitis
    Wang, Zhao
    Tan, Fei
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2020, 91 (02)
  • [23] Assessment of PD-1/PD-L1 colocalization in hepatocellular carcinoma (HCC) using bright-field double labeling and quantitative digital image analysis
    Mrowiec, T.
    Wilm, F.
    Frick-Krieger, E.
    Silva, M.
    Terracciano, L.
    Dussault, I.
    Ihling, C.
    ANNALS OF ONCOLOGY, 2018, 29
  • [24] TOX-expressing terminally exhausted tumor-infiltrating CD8+ T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer
    Han, Hye Sook
    Jeong, Seongju
    Kim, Hyunglae
    Kim, Hyung-Don
    Kim, A. Reum
    Kwon, Minsuk
    Park, Su-Hyung
    Woo, Chang Gok
    Kim, Hee Kyung
    Lee, Ki Hyeong
    Seo, Sung Pil
    Kang, Ho Won
    Kim, Won Tae
    Kim, Wun-Jae
    Yun, Seok Joong
    Shin, Eui-Cheol
    CANCER LETTERS, 2021, 499 : 137 - 147
  • [25] IL-2 synergizes with PD-1/PD-L1 blockade via CD28/CHK1 pathway to enhance CD81 T cell responses in lung squamous cell carcinoma
    Huang, S-M.
    Wu, S-P.
    Liao, R-Q.
    Dong, Z-Y.
    Tu, H.
    Xie, Z.
    Su, J.
    Yang, J-J.
    Zhang, X.
    Wu, Y-L.
    ANNALS OF ONCOLOGY, 2016, 27
  • [26] PD-1 blockade restores impaired function of ex vivo expanded CD8+T cells and enhances apoptosis in mismatch repair deficient EpCACAM+PD-L1+cancer cells
    Kumar, Rajeev
    Yu, Fang
    Zhen, Yuan-Huan
    Li, Bo
    Wang, Jun
    Yang, Yuan
    Ge, Hui-Xin
    Hu, Ping-Sheng
    Xiu, Jin
    ONCOTARGETS AND THERAPY, 2017, 10 : 3453 - 3465
  • [27] FUNCTIONAL T CELL RESTORATION INDUCED BY PD-1/PD-L1 BLOCKADE IN CHRONIC HEPATITIS B AND C IS IMPROVED BY SIMULTANEOUS MODULATION OF THE CO-STIMULATORY CD137/CD137L PATHWAY
    Fisicaro, P.
    Urbani, S.
    Valdatta, C.
    Amadei, B.
    Andreone, P.
    Loggi, E.
    Bernardi, M.
    Villa, E.
    Missale, G.
    Ferrari, C.
    JOURNAL OF HEPATOLOGY, 2009, 50 : S49 - S49
  • [28] Cyclin dependent kinase 9 (CDK9) inhibition increased efficacy of programmed cell death protein 1 (PD-1) blockade for hepatocellular carcinoma (HCC) through decreasing programmed death-ligand 1 (PD-L1) expression
    Chen, Ching-Tso
    Shao, Yu-Yun
    Hsu, Hung-Wei
    Wo, Rita R.
    Wang, Han-Yu
    Cheng, Ann-Lii
    Hsu, Chih-Hung
    CANCER RESEARCH, 2023, 83 (07)
  • [29] TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation (vol 5, pg 1834, 2024)
    Nutsch, Katherine
    Banta, Karl L.
    Wu, Thomas D.
    Tran, Charles W.
    Mittman, Stephanie
    Duong, Ellen
    Nabet, Barzin Y.
    Qu, Yan
    Williams, Katherine
    Muller, Soren
    Patil, Namrata S.
    Chiang, Eugene Y.
    Mellman, Ira
    NATURE CANCER, 2025, 6 (02) : 405 - 405
  • [30] Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma
    Wu, Yunyan
    Sang, Meixiang
    Liu, Fei
    Zhang, Jiandong
    Li, Weijing
    Li, Zhenhua
    Gu, Lina
    Zheng, Yang
    Li, Juan
    Shan, Baoen
    CARCINOGENESIS, 2020, 41 (07) : 894 - 903