P42/p44 mitogen-activated protein kinase signal transduction pathway regulates interleukin-6 expression in PC3 cells, a line of hormone-refractory prostate cancer cells

被引：7
|
作者：
Koul, S
Huang, M
Chaturvedi, L
Meacham, RB
Koul, HK
机构：
[1] Univ Colorado, Sch Med, Div Urol, Dept Surg,Signal Transduct & Mol Biol Lab, Denver, CO 80262 USA
[2] Henry Ford Hlth Sci Ctr, Detroit, MI 48202 USA
来源：
SIGNAL TRANSDUCTION PATHWAYS, CHROMATIN STRUCTURE, AND GENE EXPRESSION MECHANISMS AS THERAPEUTIC TARGETS | 2004年 / 1030卷
关键词：
p42/p44 MAP kinase; prostate cancer; IL-6; DNA synthesis; androgen-independent;
D O I：
10.1196/annals.1329.031
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanisms that regulate prostate cancer growth and proliferation are not fully understood. IL-6, a multifunctional cytokine, has been shown to play an important role in prostate cancer biology. Functional role of MAP-kinase signal transduction pathways in prostate biology has not been evaluated in detail. In the present study we evaluated the effects of modulation of p42/44 MAP kinase signal transduction pathway on IL-6 expression and secretion by PC3 cells, a line of hormone refractory prostate cancer cells. Results presented, herein, demonstrate that modulation of p42/44 MAP kinase activity results in partial inhibition of synthesis and secretion of IL-6. These data suggest that modulation of p42/p44 may result in regulation of other survival pathways as well.
引用
收藏
页码：253 / 257
页数：5
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