The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels

被引：18
|
作者：
Zylbergold, Peter [1 ]
Ramakrishnan, Nitya [1 ]
Hebert, Terence E. [1 ]
机构：
[1] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada
来源：
CHANNELS | 2010年 / 4卷 / 05期
基金：
加拿大健康研究院;
关键词：
Kir3; channels; G proteins; trafficking; neurons; cardiomyocytes; G-BETA-GAMMA; FORM STABLE COMPLEXES; RECTIFIER K+ CHANNELS; C-TERMINAL DOMAIN; GIRK CHANNELS; CRYSTAL-STRUCTURE; GABA(B) RECEPTORS; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; SIGNALING COMPLEXES; SURFACE DELIVERY;
D O I：
10.4161/chan.4.5.13327
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Kir3 channels (also known as GIRK channels) are important regulators of electrical excitability in both cardiomyocytes and neurons. Much is known regarding the assembly and function of these channels and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied effectors of heterotrimeric G proteins in general and G beta gamma subunits in particular. However, our understanding of the roles of multiple G beta gamma binding sites on Kir3 channels is still rudimentary. We discuss potential roles for G beta gamma in channel assembly and trafficking in addition to their known role in cellular signaling.
引用
收藏
页码：411 / 421
页数：11
相关论文
共 50 条
  • [21] Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
    Hibino, Hiroshi
    Inanobe, Atsushi
    Furutani, Kazuharu
    Murakami, Shingo
    Findlay, Ian
    Kurachi, Yoshihisa
    PHYSIOLOGICAL REVIEWS, 2010, 90 (01) : 291 - 366
  • [22] Channelopathies of inwardly rectifying potassium channels
    Abraham, MR
    Jahangir, A
    Alekseev, AE
    Terzic, A
    FASEB JOURNAL, 1999, 13 (14): : 1901 - 1910
  • [23] Inwardly rectifying potassium channels (Kir) in central nervous system glia: a special role for Kir4.1 in glial functions
    Butt, Arthur M.
    Kalsi, Amanpreet
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2006, 10 (01) : 33 - 44
  • [24] Interactions between GABA-B1 receptors and Kir 3 inwardly rectifying potassium channels
    David, Martin
    Richer, Maxime
    Mamarbachi, Aida M.
    Villeneuve, Louis R.
    Dupre, Denis J.
    Hebert, Terence E.
    CELLULAR SIGNALLING, 2006, 18 (12) : 2172 - 2181
  • [25] Glial inwardly rectifying potassium channels
    Horio, Y
    Kurachi, Y
    POTASSIUM ION CHANNELS: MOLECULAR STRUCTURE, FUNCTION, AND DISEASES, 1999, 46 : 471 - +
  • [26] Inwardly rectifying K+ (Kir) channels in Drosophila -: A crucial role of cellular milieu factors for Kir channel function
    Döring, F
    Wischmeyer, E
    Kühnlein, RP
    Jäckle, H
    Karschin, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (28) : 25554 - 25561
  • [27] Discovery of an inward rectifying potassium channel inhibitor with preference for Kir2.3 and Kir3
    Raphemot, Rene
    Lonergan, Daniel
    Nguyen, Thuy T.
    Utley, Thomas J.
    Gogliotti, Rocco
    Hopkins, Corey R.
    Lewis, L. Michelle
    Lindsley, Craig W.
    Weaver, C. David
    Denton, Jerod S.
    FASEB JOURNAL, 2011, 25
  • [28] Evidence of a role for the inwardly rectifying potassium channel (Kir) 4.1 in oligodendrocyte development
    不详
    JOURNAL OF ANATOMY, 2005, 206 (05) : 493 - 494
  • [29] Basolateral sorting or an inwardly rectifying potassium channel, Kir 2.3, by PDZ proteins.
    Olsen, O
    Merot, J
    Brejon, M
    Welling, PA
    FASEB JOURNAL, 2000, 14 (04): : A101 - A101
  • [30] Identification of inwardly rectifying potassium channel (Kir2)associated brain proteins
    Leonoudakis, D
    Radeke, CM
    Anderson, S
    Yates, JR
    Vandenberg, CA
    MOLECULAR BIOLOGY OF THE CELL, 2002, 13 : 221A - 222A
12345