The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels

被引：18

作者：

Zylbergold, Peter ^{[1
]}

Ramakrishnan, Nitya ^{[1
]}

Hebert, Terence E. ^{[1
]}

机构：

[1] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada

来源：

CHANNELS | 2010年 / 4卷 / 05期

基金：

加拿大健康研究院;

关键词：

Kir3; channels; G proteins; trafficking; neurons; cardiomyocytes; G-BETA-GAMMA; FORM STABLE COMPLEXES; RECTIFIER K+ CHANNELS; C-TERMINAL DOMAIN; GIRK CHANNELS; CRYSTAL-STRUCTURE; GABA(B) RECEPTORS; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; SIGNALING COMPLEXES; SURFACE DELIVERY;

D O I：

10.4161/chan.4.5.13327

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kir3 channels (also known as GIRK channels) are important regulators of electrical excitability in both cardiomyocytes and neurons. Much is known regarding the assembly and function of these channels and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied effectors of heterotrimeric G proteins in general and G beta gamma subunits in particular. However, our understanding of the roles of multiple G beta gamma binding sites on Kir3 channels is still rudimentary. We discuss potential roles for G beta gamma in channel assembly and trafficking in addition to their known role in cellular signaling.

引用

页码：411 / 421

页数：11

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