Drug-binding to Distinct Sites of the Multidrug Exporter P-glycoprotein

被引:0
|
作者
Urbatsch, Ina L. [1 ]
Swartz, Douglas J. [2 ]
Singh, Anukriti [1 ]
Katz, Courtney [1 ]
Jackson, Benjamin T. [1 ]
Weber, Joachim [3 ]
机构
[1] Texas Tech Univ, Hlth Sci Ctr, Cell Biol & Biochem, Lubbock, TX 79430 USA
[2] Lubbock Christian Univ, Lubbock, TX USA
[3] Texas Tech Univ, Chem & Biochem, Lubbock, TX 79409 USA
关键词
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
91-Plat
引用
收藏
页码:19A / 19A
页数:1
相关论文
共 50 条
  • [21] EXPRESSION OF P-GLYCOPROTEIN GENE IN MARINE SPONGES - IDENTIFICATION AND CHARACTERIZATION OF THE 125 KDA DRUG-BINDING GLYCOPROTEIN
    KURELEC, B
    KRCA, S
    PIVCEVIC, B
    UGARKOVIC, D
    BACHMANN, M
    IMSIECKE, G
    MULLER, WEG
    CARCINOGENESIS, 1992, 13 (01) : 69 - 76
  • [22] Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site
    Loo, TW
    Bartlett, MC
    Clarke, DM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (23) : 20449 - 20452
  • [23] Do Drugs Have Access to the P-Glycoprotein Drug-Binding Pocket through Gates?
    Ferreira, Ricardo J.
    Ferreira, Maria-Jose U.
    dos Santos, Daniel J. V. A.
    JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2015, 11 (10) : 4525 - 4529
  • [24] Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket
    Loo, Tip W.
    Bartlett, M. Claire
    Clarke, David M.
    BIOCHEMICAL JOURNAL, 2006, 399 : 351 - 359
  • [25] The Effect of the Lipid Environment on Drug Binding and Transport by the P-Glycoprotein Multidrug Transporter
    Sharom, Frances Jane
    Clay, Adam T.
    FASEB JOURNAL, 2012, 26
  • [26] Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane
    Loo, TW
    Clarke, DM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (50) : 39272 - 39278
  • [27] Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis
    Martin, C
    Berridge, G
    Mistry, P
    Higgins, C
    Charlton, P
    Callaghan, R
    BIOCHEMISTRY, 2000, 39 (39) : 11901 - 11906
  • [28] Identification of drug interaction sites in P-glycoprotein
    Greenberger, LM
    ABC TRANSPORTERS: BIOCHEMICAL, CELLULAR, AND MOLECULAR ASPECTS, 1998, 292 : 307 - 317
  • [29] Identification of residues in the drug-binding site of human P-glycoprotein using a thiol-reactive substrate
    Loo, TW
    Clarke, DM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (51) : 31945 - 31948
  • [30] CHARACTERIZATION OF DRUG-BINDING SITES ON ALPHA-1-ACID GLYCOPROTEIN
    MARUYAMA, T
    OTAGIRI, M
    TAKADATE, A
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (06) : 1688 - 1691