A platform direct compression formulation for low dose sustained-release tablets enabled by a dual particle engineering approach

被引：9

作者：

Sun, Wei-Jhe ^{[1
]}

Chen, Hongbo ^{[1
]}

Aburub, Aktham ^{[2
]}

Sun, Changquan Calvin ^{[1
]}

机构：

[1] Univ Minnesota, Dept Pharmaceut, Coll Pharm, Pharmaceut Mat Sci & Engn Lab, 9-127B Weaver Densford Hall,308 Harvard St SE, Minneapolis, MN 55455 USA

[2] Eli Lilly & Co, Lilly Res Labs, Small Mol Design & Dev, Indianapolis, IN 46285 USA

来源：

POWDER TECHNOLOGY | 2019年 / 342卷

关键词：

Sustained release; Particle engineering; Direct compression; Nanocoating; Acetaminophen; Celecoxib; Nicotinamide; Tableting; FLOW PROPERTIES; MICROCRYSTALLINE CELLULOSE; EXPEDITED DEVELOPMENT; SYSTEMS;

D O I：

10.1016/j.powtec.2018.10.054

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Content uniformity (CU) is a well-recognized challenge for low-dose direct compression (DC) tablet formulations. Using a dual particle engineering approach that involves a) forming a segregation-resistant drug-carrier composite to improve CU and b) nanocoating HPMC to enhance flowability, we have developed a platform DC formulation for preparing low-dose drug sustained-release (SR) tablets with excellent CU. In addition to demonstrated robustness in manufacturability, this platform formulation has the flexibility for modifying drug release rate. Thus, it is useful for expedited and material-sparing development of low dose SR tablets using the economical DC process. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：856 / 863

页数：8

共 11 条

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Sun, Wei-Jhe
Aburub, Aktham
Sun, Changquan Calvin
JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 106 (07) : 1772 - 1777
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STP PHARMA SCIENCES, 2002, 12 (05): : 287 - 292
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RESEARCH AND INDUSTRY, 1985, 30 (03): : 189 - 191
[7] Further enhancement of the sustained-release properties and stability of direct compression gel matrix bilayer tablets by controlling the particle size of HPMC and drug microencapsulation
Liu, Tong
Wang, Jiahui
Feng, Yupeng
Wang, Haoran
Xu, Yunlong
Yin, Tian
Zhang, Yu
He, Haibing
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Tang, Xing
POWDER TECHNOLOGY, 2024, 448
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AAPS PHARMSCITECH, 2005, 6 (02):
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Pongjanyakul T.
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[10] A formulation approach for development of HPMC-based sustained release tablets for tolterodine tartrate with a low release variation
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Choi, Jae-Seung
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Xu, Wei-Juan
Yang, Mingshi
Lee, Beom-Jin
Cui, Jing-Hao
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2013, 39 (11) : 1720 - 1730

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