GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging β-amyloid plaques in human brain

被引：50

作者：

Yao, Cheng-Hsiang ^{[2
,3
]}

Lin, Kun-Ju ^{[1
,2
,3
]}

Weng, Chi-Chang ^{[1
]}

Hsiao, Ing-Tsung ^{[1
,2
,3
]}

Ting, Yi-Shu ^{[2
,3
]}

Yen, Tzu-Chen ^{[1
,2
,3
]}

Jan, Tong-Rong ^{[4
]}

Skovronsky, Daniel ^{[5
]}

Kung, Mei-Ping ^{[2
,3
,6
]}

Wey, Shiaw-Pyng ^{[1
,2
,3
]}

机构：

[1] Chang Gung Univ, Dept Med Imaging & Radiol Sci, Tao Yuan 333, Taiwan

[2] Chang Gung Mem Hosp, Dept Nucl Med, Taipei, Taiwan

[3] Chang Gung Mem Hosp, Mol Imaging Ctr, Taipei, Taiwan

[4] Natl Taiwan Univ, Dept & Grad Inst Vet Med, Taipei 10764, Taiwan

[5] Avid Radiopharmaceut Inc, Philadelphia, PA 19104 USA

[6] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

来源：

APPLIED RADIATION AND ISOTOPES | 2010年 / 68卷 / 12期

关键词：

Alzheimer's disease; PET tracer synthesis; beta-amyloid plaque imaging; ALZHEIMERS-DISEASE; PET; RADIOLIGAND; DEPOSITION; PROGRESS;

D O I：

10.1016/j.apradiso.2010.07.001

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of F-18-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of beta-amyloid (A beta) plaques in the brain of Alzheimer's disease patients [F-18]AV-45 was prepared in 105 min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions The overall yield was 25.4 +/- 7 7% with a final radiochemical purity of 95.3 +/- 2.2% (n=19). The specific activity of [F-18]AV-45 reached as high as 470 +/- 135 TBq/mmol (n=19). The present studies show that [F-18]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2293 / 2297

页数：5

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