GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging β-amyloid plaques in human brain

被引：50
|
作者：
Yao, Cheng-Hsiang [2 ,3 ]
Lin, Kun-Ju [1 ,2 ,3 ]
Weng, Chi-Chang [1 ]
Hsiao, Ing-Tsung [1 ,2 ,3 ]
Ting, Yi-Shu [2 ,3 ]
Yen, Tzu-Chen [1 ,2 ,3 ]
Jan, Tong-Rong [4 ]
Skovronsky, Daniel [5 ]
Kung, Mei-Ping [2 ,3 ,6 ]
Wey, Shiaw-Pyng [1 ,2 ,3 ]
机构：
[1] Chang Gung Univ, Dept Med Imaging & Radiol Sci, Tao Yuan 333, Taiwan
[2] Chang Gung Mem Hosp, Dept Nucl Med, Taipei, Taiwan
[3] Chang Gung Mem Hosp, Mol Imaging Ctr, Taipei, Taiwan
[4] Natl Taiwan Univ, Dept & Grad Inst Vet Med, Taipei 10764, Taiwan
[5] Avid Radiopharmaceut Inc, Philadelphia, PA 19104 USA
[6] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
来源：
APPLIED RADIATION AND ISOTOPES | 2010年 / 68卷 / 12期
关键词：
Alzheimer's disease; PET tracer synthesis; beta-amyloid plaque imaging; ALZHEIMERS-DISEASE; PET; RADIOLIGAND; DEPOSITION; PROGRESS;
D O I：
10.1016/j.apradiso.2010.07.001
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of F-18-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of beta-amyloid (A beta) plaques in the brain of Alzheimer's disease patients [F-18]AV-45 was prepared in 105 min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions The overall yield was 25.4 +/- 7 7% with a final radiochemical purity of 95.3 +/- 2.2% (n=19). The specific activity of [F-18]AV-45 reached as high as 470 +/- 135 TBq/mmol (n=19). The present studies show that [F-18]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use. (c) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2293 / 2297
页数：5
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