COVID-19 vaccine induced interstitial lung disease

被引：24

作者：

Yoshifuji, Ayumi ^{[1
]}

Ishioka, Kota ^{[1
]}

Masuzawa, Yuya ^{[2
]}

Suda, Shuntaro ^{[2
]}

Murata, Saori ^{[1
]}

Uwamino, Yoshifumi ^{[3
]}

Fujino, Motoko ^{[4
]}

Miyahara, Hiromi ^{[1
]}

Hasegawa, Naoki ^{[5
]}

Ryuzaki, Munekazu ^{[1
]}

Hoshino, Haruhiko ^{[1
]}

Sekine, Kazuhiko ^{[2
]}

机构：

[1] Tokyo Saiseikai Cent Hosp, Dept Internal Med, Tokyo, Japan

[2] Tokyo Saiseikai Cent Hosp, Dept Emergency & Crit Care Med, Tokyo, Japan

[3] Keio Univ, Dept Lab Med, Sch Med, Tokyo, Japan

[4] Tokyo Saiseikai Cent Hosp, Dept Pediat, Tokyo, Japan

[5] Keio Univ, Dept Infect Dis, Sch Med, Tokyo, Japan

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2022年 / 28卷 / 01期

关键词：

COVID-19; vaccine; Adverse events; Drug-induced interstitial lung disease; INDUCED PNEUMONITIS; DIAGNOSIS;

D O I：

10.1016/j.jiac.2021.09.010

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A 60-year-old man presented with dyspnea four days after the second dose of the coronavirus disease (COVID-19) vaccine. Imaging revealed extensive ground-glass opacification. Blood tests were notable for elevated KL-6 levels. Bronchoalveolar lavage fluid analysis showed increased lymphocyte-dominant inflammatory cells and decreased CD4/CD8 ratio. These findings were consistent with the diagnosis of drug-induced interstitial lung disease (DIILD). To the best of our knowledge, this has never been reported in previous literature. Treatment with glucocorticoids relieved his symptoms. This paper highlights that although extremely rare, COVID-19 vaccine could cause DIILD, and early diagnosis and treatment are crucial to improve patient outcomes.

引用

页码：95 / 98

页数：4

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