DNA vaccines and apoptosis: to kill or not to kill?

被引：19
|
作者：
Leitner, WW [1 ]
Restifo, NP [1 ]
机构：
[1] NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 01期
关键词：
D O I：
10.1172/JCI200319069
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The apoptotic machinery has become the latest target of vaccinologists attempting to improve the efficacy of DNA vaccines. While workers have previously sought to induce apoptotic death in transfected DCs as a means to activate immunity, a new approach (see related article on pages 109-117) instead seeks to delay apoptosis in host DCs after DNA vaccination.
引用
收藏
页码：22 / 24
页数：3
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