Recent Advances in the Rational Drug Design Based on Multi-target Ligands

被引:27
|
作者
Yang, Ting [1 ]
Sui, Xin [1 ,2 ]
Yu, Bing [1 ,2 ]
Shen, Youqing [1 ,3 ,4 ]
Cong, Hailin [1 ,2 ]
机构
[1] Qingdao Univ, Coll Mat Sci & Engn, Inst Biomed Mat & Engn, Qingdao 266071, Peoples R China
[2] Qingdao Univ, Coll Chem & Chem Engn, State Key Lab Biofibers & Ecotext, Qingdao 266071, Peoples R China
[3] Zhejiang Univ, Coll Chem & Biol Engn, Minist Educ, Ctr Bionanoengn, Hangzhou 310027, Peoples R China
[4] Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Biomass Chem Engn, Minist Educ, Hangzhou 310027, Peoples R China
基金
中国国家自然科学基金;
关键词
Multitarget drugs; Alzheimer's disease; Parkinson's disease; cancer; neglected tropical diseases; pharmacokinetic parameters; TARGET-DIRECTED LIGANDS; ADENOSINE A(2A) RECEPTORS; MONOAMINE-OXIDASE-B; VIVO BIOLOGICAL EVALUATION; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; IN-VITRO; MOLECULAR DOCKING;
D O I
10.2174/0929867327666200102120652
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Multi-target drugs have gained considerable attention in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance. Single-target drugs, although highly selective, may not necessarily have better efficacy or fewer side effects. Therefore, more attention is being paid to developing drugs that work on multiple targets at the same time, but developing such drugs is a huge challenge for medicinal chemists. Each target must have sufficient activity and have sufficiently characterized pharmacokinetic parameters. Multi-target drugs, which have long been known and effectively used in clinical practice, are briefly discussed in the present article. In addition, in this review, we will discuss the possible applications of multi-target ligands to guide the repositioning of prospective drugs.
引用
收藏
页码:4720 / 4740
页数:21
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