Copper-catalyzed asymmetric propargylic substitution reactions of propargylic acetates with amines

被引：189
|
作者：
Hattori, Gaku [1 ]
Matsuzawa, Hiroshi [1 ]
Miyake, Yoshihiro [1 ]
Nishibayashi, Yoshiaki [1 ]
机构：
[1] Univ Tokyo, Sch Engn, Inst Engn Innovat, Bunkyo Ku, Tokyo 1138656, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 20期
关键词：
amination; asymmetric catalysis; copper; nucleophilic substitution; P ligands;
D O I：
10.1002/anie.200800276
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Flexing your bipheps: Enantioselective propargylic substitution reactions of propargylic acetates with amines catalyzed by a copper-(R)-Cl-MeO-biphep or -binap complex give the corresponding propargylic amines in excellent yields with up to 89% ee. The reaction described may provide a novel synthetic method for the preparation of chiral propargylic amines. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3781 / 3783
页数：3
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