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Newcastle Univ, Inst Ageing & Hlth, UK NIHR Biomed Res Ctr Ageing & Age Related Dis, Cardiovasc Theme & Falls & Syncope Serv, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Inst Ageing & Hlth, UK NIHR Biomed Res Ctr Ageing & Age Related Dis, Cardiovasc Theme & Falls & Syncope Serv, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England