G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes

被引：39
|
作者：
Bonsignore, Riccardo [1 ,2 ]
Terenzi, Alessio [3 ,4 ,5 ]
Spinello, Angelo [1 ,2 ]
Martorana, Annamaria [1 ]
Lauria, Antonino [1 ]
Almerico, Anna Maria [1 ]
Keppler, Bernhard K. [3 ,4 ,5 ]
Barone, Giampaolo [1 ,2 ]
机构：
[1] Dipartimento Sci Tecnol Biol Chim & Farmaceut, Viale Sci,Edificio 17, I-90128 Palermo, Italy
[2] Ist EuroMediterraneo Sci & Tecnol, Piazzetta Briuccia 20-21, I-90139 Palermo, Italy
[3] Univ Vienna, Inst Inorgan Chem, Waehringerstr 42, A-1090 Vienna, Austria
[4] Univ Vienna, Res Platform Translat Canc Therapy Res, Vienna, Austria
[5] Med Univ Vienna, Vienna, Austria
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2016年 / 161卷
关键词：
Binding constant; Circular dichroism; Computational chemistry; DNA G-quadruplex; nickel zinc; SALICYLIDENE ORTHO-PHENYLENDIIMINATE; TELOMERIC G-QUADRUPLEX; CIRCULAR-DICHROISM; METAL-COMPLEXES; NUCLEIC-ACIDS; FORCE-FIELD; NATIVE DNA; STABILIZATION; RECOGNITION; COPPER(II);
D O I：
10.1016/j.jinorgbio.2016.05.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Novel nickel(II) (1) and zinc(II) (2) complexes of a Salen-like ligand, carrying a pyrimidine ring on the N,N' bridge, were synthesized and characterized. Their interaction with duplex and G-quadruplex DNA was investigated in aqueous solution through UV-visible absorption, circular dichroism and viscometry measurements. The results obtained point out that, while the zinc(II) complex does not interact with both duplex and G-quadruplex DNA, the nickel(II) complex 1 binds preferentially to G-quadruplex respect to duplex-DNA, with values of the DNA-binding constants, K-b, 2.6 x 10(5) M-1 and 3.5 x 10(4) M-1, respectively. Molecular dynamics simulations provided an atomic level model of the top-stacking binding occurring between 1 and hTelo (a 22-mer sequence oligonucleotide) in G-quadruplex conformation. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：115 / 121
页数：7
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