A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis

被引：4
|
作者：
Byg, Keld-Erik [1 ,2 ,3 ,4 ,10 ]
Illes, Zsolt [2 ,3 ,5 ]
Sejbaek, Tobias [3 ,6 ,7 ]
Nguyen, Nina [8 ]
Moller, Soren [4 ,9 ]
Lambertsen, Kate L. [3 ,5 ]
Nielsen, Helle H. [2 ,3 ,5 ]
Ellingsen, Torkell [1 ,4 ]
机构：
[1] Odense Univ Hosp, Rheumatol Res Unit, JB Winsloewsvej 4, DK-5000 Odense, Denmark
[2] Odense Univ Hosp, Dept Neurol, JB Winsloewsvej 4, DK-5000 Odense, Denmark
[3] Univ Southern Denmark, Dept Clin Res, BRIDGE Brain Res Interdisciplinary Guided Excellen, JB Winsloewsvej 19, DK-5000 Odense, Denmark
[4] Univ Southern Denmark, Dept Clin Res, JB Winsloewsvej 19, DK-5000 Odense, Denmark
[5] Univ Southern Denmark, Inst Mol Med, Dept Neurobiol Res, JB Winsloewsvej 21, DK-5000 Odense, Denmark
[6] South West Jutland Univ Hosp Southern Denmark, Dept Neurol, Finsensgade 35, DK-6700 Esbjerg, Denmark
[7] Univ Southern Denmark, Dept Reg Hlth Res, JB Winsloewsvej 19, DK-5000 Odense, Denmark
[8] Odense Univ Hosp, Dept Radiol, JB Winsloewsvej 4, DK-5000 Odense, Denmark
[9] Odense Univ Hosp, Open Patient data Explorat Network, JB Winsloewsvej 9a, DK-5000 Odense, Denmark
[10] Univ Southern Denmark, Odense Univ Hosp, Dept Rheumatol, Rheumatol Res Unit, J B Win Sloewsvej 4, DK-5000 Odense, Denmark
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2022年 / 369卷
关键词：
Neurosarcoidosis; Treatment; MRI; mRS; SDMT; FAS; DIGIT MODALITIES TEST; QUALITY-OF-LIFE; EVERYDAY COGNITIVE FAILURE; FATIGUE ASSESSMENT SCALE; LONG-TERM OUTCOMES; CLINICAL-MANIFESTATIONS; DEPRESSIVE SYMPTOMS; INVENTORY-II; DOUBLE-BLIND; SARCOIDOSIS;
D O I：
10.1016/j.jneuroim.2022.577913
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Methods: Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up. Results: The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged. Conclusions: 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement.
引用
收藏
页数：10
相关论文
共 50 条
  • [41] Prognosis of newly diagnosed epilepsy: Preliminary results of a two-year prospective follow-up study
    Dogan, EA
    Aktekin, B
    Senol, Y
    Oguz, Y
    EPILEPSIA, 2005, 46 : 130 - 130
  • [42] One-year follow-up of children hospitalized with COVID-19: a prospective cohort study
    Schmidt, Caroline Jacoby
    Casassola, Giovana Morin
    Affeldt, Guilherme Hoff
    Morais, Debora Sana
    Borges Alvarenga, Leticia Kras
    Miller, Cristina
    Ziegler, Bruna
    JORNAL BRASILEIRO DE PNEUMOLOGIA, 2023, 49 (05)
  • [43] Adolescents with substance abuse problems in outpatient treatment: A one-year prospective follow-up study
    Anderberg, Mats
    Dahlberg, Mikael
    Wennberg, Peter
    NORDIC STUDIES ON ALCOHOL AND DRUGS, 2021, 38 (05) : 466 - 479
  • [44] A One-Year Prospective Follow-Up Study on the Health Profile of Hikikomori Living in Hong Kong
    Yuen, John W. M.
    Wong, Victor C. W.
    Tam, Wilson W. S.
    So, Ka Wing
    Chien, Wai Tong
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2019, 16 (04)
  • [45] Widespread pain and neck pain in schoolchildren. A prospective one-year follow-up study
    Mikkelsson, M
    Sourander, A
    Salminen, JJ
    Kautiainen, H
    Piha, J
    ACTA PAEDIATRICA, 1999, 88 (10) : 1119 - 1124
  • [46] One-year follow-up after incisional hernia treatment: results of a prospective randomized study
    Venclauskas, L.
    Maleckas, A.
    Kiudelis, M.
    HERNIA, 2010, 14 (06) : 575 - 582
  • [47] Vaginal dilation treatment in women with vaginal hypoplasia: a prospective one-year follow-up study
    Callens, Nina
    Weyers, Steven
    Monstrey, Stan
    Stockman, Sabine
    van Hoorde, Birgit
    van Hoecke, Eline
    De Cuypere, Griet
    Hoebeke, Piet
    Cools, Martine
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2014, 211 (03)
  • [48] One-year follow-up after incisional hernia treatment: results of a prospective randomized study
    L. Venclauskas
    A. Maleckas
    M. Kiudelis
    Hernia, 2010, 14 : 575 - 582
  • [49] Seven-Year Follow-up of Patients Diagnosed with Atypical Odontalgia: A Prospective Study
    Pigg, Maria
    Svensson, Peter
    Drangsholt, Mark
    List, Thomas
    JOURNAL OF OROFACIAL PAIN, 2013, 27 (02): : 151 - 164
  • [50] Alzemon: a prospective follow-up study of eslicarbazepine acetate monotherapy in patients with newly diagnosed epilepsy
    Hernandez-Rubio, Lidia
    Asensio-Asensio, Montserrat
    Tortosa-Conesa, Diego
    Alfaro-Saez, Aranzazu
    Garcia-Escriva, Alexandre
    Diaz-Roman, Monica
    Montoya, Javier
    Angeles Mendez-Miralles, M.
    Bertol-Alegre, Vicente
    Dolores Castro-Vilanova, M.
    Luisa Galiano, M.
    Empar Blanco-Canto, M.
    Lopez-Gonzalez, Fatima
    REVISTA DE NEUROLOGIA, 2021, 72 (08) : 263 - 268
12345