A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis

被引：4

作者：

Byg, Keld-Erik ^{[1
,2
,3
,4
,10
]}

Illes, Zsolt ^{[2
,3
,5
]}

Sejbaek, Tobias ^{[3
,6
,7
]}

Nguyen, Nina ^{[8
]}

Moller, Soren ^{[4
,9
]}

Lambertsen, Kate L. ^{[3
,5
]}

Nielsen, Helle H. ^{[2
,3
,5
]}

Ellingsen, Torkell ^{[1
,4
]}

机构：

[1] Odense Univ Hosp, Rheumatol Res Unit, JB Winsloewsvej 4, DK-5000 Odense, Denmark

[2] Odense Univ Hosp, Dept Neurol, JB Winsloewsvej 4, DK-5000 Odense, Denmark

[3] Univ Southern Denmark, Dept Clin Res, BRIDGE Brain Res Interdisciplinary Guided Excellen, JB Winsloewsvej 19, DK-5000 Odense, Denmark

[4] Univ Southern Denmark, Dept Clin Res, JB Winsloewsvej 19, DK-5000 Odense, Denmark

[5] Univ Southern Denmark, Inst Mol Med, Dept Neurobiol Res, JB Winsloewsvej 21, DK-5000 Odense, Denmark

[6] South West Jutland Univ Hosp Southern Denmark, Dept Neurol, Finsensgade 35, DK-6700 Esbjerg, Denmark

[7] Univ Southern Denmark, Dept Reg Hlth Res, JB Winsloewsvej 19, DK-5000 Odense, Denmark

[8] Odense Univ Hosp, Dept Radiol, JB Winsloewsvej 4, DK-5000 Odense, Denmark

[9] Odense Univ Hosp, Open Patient data Explorat Network, JB Winsloewsvej 9a, DK-5000 Odense, Denmark

[10] Univ Southern Denmark, Odense Univ Hosp, Dept Rheumatol, Rheumatol Res Unit, J B Win Sloewsvej 4, DK-5000 Odense, Denmark

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2022年 / 369卷

关键词：

Neurosarcoidosis; Treatment; MRI; mRS; SDMT; FAS; DIGIT MODALITIES TEST; QUALITY-OF-LIFE; EVERYDAY COGNITIVE FAILURE; FATIGUE ASSESSMENT SCALE; LONG-TERM OUTCOMES; CLINICAL-MANIFESTATIONS; DEPRESSIVE SYMPTOMS; INVENTORY-II; DOUBLE-BLIND; SARCOIDOSIS;

D O I：

10.1016/j.jneuroim.2022.577913

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Methods: Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up. Results: The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged. Conclusions: 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement.

引用

页数：10

共 50 条

[1] A PROSPECTIVE, ONE-YEAR FOLLOW-UP STUDY OF PATIENTS NEWLY DIAGNOSED WITH NEUROSARCOIDOSIS
Byg, K. E.
Illes, Z.
Sejbaek, T.
Nguyen, N.
Moller, S.
Lambertsen, K.
Nielsen, H.
Ellingsen, T.
ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 : 1015 - 1015
[2] One-year follow-up of newly diagnosed irritable bowel syndrome patients
Ruigómez, A
Wallander, MA
Johansson, S
Rodríguez, LAG
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 1999, 13 (08) : 1097 - 1102
[3] One-year follow-up of the Polish subset of the RecordAF registry of patients with newly diagnosed atrial fibrillation
Opolski, Grzegorz
Kosior, Dariusz A.
Kurzelewski, Michal
Breithardt, Guenter
POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL MEDICINE, 2013, 123 (05): : 238 - 245
[4] Sports injuries in floorball:: A prospective one-year follow-up study
Snellman, K
Parkkari, J
Kannus, P
Leppälä, J
Vuori, I
Järvinen, M
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2001, 22 (07) : 531 - 536
[5] A ONE-YEAR FOLLOW-UP OF FATIGUED PATIENTS
VALDINI, AF
STEINHARDT, S
VALICENTI, J
JAFFE, A
JOURNAL OF FAMILY PRACTICE, 1988, 26 (01): : 33 - 38
[6] Periradicular surgery of molars: a prospective clinical study with a one-year follow-up
von Arx, T
Gerber, C
Hardt, N
INTERNATIONAL ENDODONTIC JOURNAL, 2001, 34 (07) : 520 - 525
[7] ONE-YEAR CONTRACEPTIVE FOLLOW-UP OF ADOLESCENT PATIENTS
JORGENSEN, V
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1973, 115 (04) : 484 - 486
[8] Alexithymia and depression - a one-year follow-up study
Saarijarvi, SP
Salminen, JK
Toikka, T
EUROPEAN PSYCHIATRY, 2002, 17 : 128S - 128S
[9] UVULOPALATOPHARYNGOPLASTY - ONE-YEAR FOLLOW-UP
CONWAY, W
FUJITA, S
ZORICK, F
SICKLESTEEL, J
ROEHRS, T
WITTIG, R
ROTH, T
CHEST, 1985, 88 (03) : 385 - 387
[10] FOLLOW-UP - ONE-YEAR LATER
MCLAUGHLIN, LR
WILSON LIBRARY BULLETIN, 1977, 51 (09) : 725 - 726

← 1 2 3 4 5 →