Targeting the DNA damage response via chemical exhaustion of replication protein A (RPA): Development and anti-cancer activity of small molecule RPA inhibitors

被引:0
|
作者
Turchi, J. [1 ]
Gavande, N. [2 ]
Vandervere-Carozza, P. [2 ]
Pawelczak, K. [3 ]
机构
[1] Indiana Univ Sch Med, Med & Biochem & Mol Biol, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Med, Indianapolis, IN 46202 USA
[3] NERx Biosci, Res, Indianapolis, IN USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
77 (PB-028
引用
收藏
页码:E33 / E33
页数:1
相关论文
共 38 条
  • [21] Advances in Small-Molecule Dual Inhibitors Targeting EGFR and HER2 Receptors as Anti-Cancer Agents
    Kang, Jia-Xiong
    Li, Chao
    Cheng, Yi-Mei
    Huang, Mou-Xin
    Zhao, Guang-Kuan
    Jin, Zhi-Liang
    Qi, Xiao-Wei
    Gu, Jing
    Ouyang, Qin
    CURRENT MEDICINAL CHEMISTRY, 2024,
  • [22] Small Molecule B-RAF Inhibitors as Anti-Cancer Therapeutics: Advances in Discovery, Development, and Mechanistic Insights
    Anaya, Yamile Abuchard
    Bracho, Ricardo Pequeno
    Chauhan, Subhash C.
    Tripathi, Manish K.
    Bandyopadhyay, Debasish
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (06)
  • [23] Anti-cancer immune responses to DNA damage response inhibitors: Molecular mechanisms and progress toward clinical translation
    Carlsen, Lindsey
    El-Deiry, Wafik S.
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [24] Identification and characterization of small molecule inhibitors targeting Eya phosphatase activity for anti-breast cancer therapy
    Krueger, Aaron
    Dehdashti, Seameen
    Southhall, Noel
    Patnaik, Samarjit
    Marugan, Juan
    Zheng, Wei
    Ford, Heide
    Zhao, Rui
    CANCER RESEARCH, 2011, 71
  • [25] BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response
    Li, Zhenhai
    Xu, Wenchao
    Chen, Feng
    Zhang, Jun
    Zhu, Wei-Guo
    GENES & DISEASES, 2024, 11 (01) : 19 - 22
  • [26] Synthetic, small molecule glycosaminoglycan mimetics induce novel anti-cancer activity through preferential targeting of a growth factor receptor
    O'Hara, Connor
    Morla, Shravan
    Ongolu, Ravikumar
    Patel, Nirmita
    Boothello, Rio
    Patel, Bhaumik
    Desai, Umesh
    CANCER RESEARCH, 2022, 82 (12)
  • [27] Chemical Inhibition of RPA by HAMNO Alters Cell Cycle Dynamics by Impeding DNA Replication and G2-to-M Transition but Has Little Effect on the Radiation-Induced DNA Damage Response
    Dueva, Rositsa
    Krieger, Lisa Marie
    Li, Fanghua
    Luo, Daxian
    Xiao, Huaping
    Stuschke, Martin
    Metzen, Eric
    Iliakis, George
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (19)
  • [28] Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress
    Aggarwal, Monika
    Sommers, Joshua A.
    Shoemaker, Robert H.
    Brosh, Robert M., Jr.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (04) : 1525 - 1530
  • [29] Antisense oligonucleotide inhibitors of isozymes of protein kinase C: In vitro and in vivo activity, and clinical development as anti-cancer therapeutics
    McGraw, K
    McKay, R
    Miraglia, L
    Boggs, RT
    Pribble, JP
    Muller, M
    Geiger, T
    Fabbro, D
    Dean, NM
    ANTI-CANCER DRUG DESIGN, 1997, 12 (05): : 315 - 326
  • [30] Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity
    Kong, Gui-Mei
    Yu, Min
    Gu, Zhongping
    Chen, Zhi
    Xu, Rui-Ming
    O'Bryant, Deon
    Wang, Zhengxin
    PLOS ONE, 2017, 12 (08):