Bilateral and unilateral hippocampal inactivation did not differ in their effect on consolidation processes in the Morris water maze

被引：9
|
作者：
Cimadevilla, Jose M. [1 ]
Miranda, Ruben [2 ]
Lopez, Laudino [3 ]
Arias, Jorge L. [3 ]
机构：
[1] Univ Almeria, Dept Neurosci, Almeria 04007, Spain
[2] Univ Baleares, Dept Psychol, Palma De Mallorca, Spain
[3] Univ Oviedo, Dept Psychol, Oveido, Spain
来源：
INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2008年 / 118卷 / 05期
关键词：
acquisition; navigation; rat; retrieval; spatial memory; TTX;
D O I：
10.1080/00207450701242818
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Consolidation processes were studied in the rat by using functional inactivation techniques. Previous results showed that unilateral hippocampal inactivation alters consolidation. It is not clear if bilateral treatments increase the impairment. Wistar rats were trained in the Morris water maze during 4 consecutive days. Subjects received saline or tetrodotoxin in the dorsal hippocampus 1 min after training. Results showed that bilateral as well as unilateral treatments impair consolidation to the same degree, as shown by the mean latency to reach the platform. In both cases, the impairment is only visible in the first trial of the session following the blockade.
引用
下载
收藏
页码：619 / 626
页数：8
相关论文
共 50 条
  • [31] BILATERAL KNIFE CUTS TO THE PERFORANT PATH DISRUPT SPATIAL-LEARNING IN THE MORRIS WATER MAZE
    SKELTON, RW
    MCNAMARA, RK
    HIPPOCAMPUS, 1992, 2 (01) : 73 - 80
  • [32] VISUALLY-GUIDED MAZE-LEARNING IN MAN - EFFECTS OF BILATERAL HIPPOCAMPAL, BILATERAL FRONTAL, AND UNILATERAL CEREBRAL-LESIONS
    MILNER, B
    NEUROPSYCHOLOGIA, 1965, 3 (04) : 317 - 338
  • [33] Increase of the hippocampal theta activity in the Morris water maze reflects learning rather than motor activity
    Olvera-Cortés, E
    Guevara, MA
    González-Burgos, I
    BRAIN RESEARCH BULLETIN, 2004, 62 (05) : 379 - 384
  • [34] Distinct epigenetic and gene expression changes in rat hippocampal neurons after Morris water maze training
    Carter, Sylvia D.
    Mifsud, Karen R.
    Reul, Johannes M. H. M.
    FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2015, 9 : 1 - 13
  • [35] Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: Relationship to Morris water maze performance
    El-Bakri, NK
    Islam, A
    Zhu, SW
    Elhassan, A
    Mohammed, A
    Winblad, B
    Adem, A
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2004, 8 (04): : 537 - 544
  • [36] Correlation of hippocampal morphological changes and Morris water maze performance after cortical contusion injury in rats
    Clausen, F
    Lewén, A
    Marklund, N
    Olsson, Y
    McArthur, DL
    Hillered, L
    NEUROSURGERY, 2005, 57 (01) : 154 - 162
  • [37] Kindling of hippocampal field CA1 impairs spatial learning and retention in the Morris water maze
    Gilbert, TH
    McNamara, RK
    Corcoran, ME
    BEHAVIOURAL BRAIN RESEARCH, 1996, 82 (01) : 57 - 66
  • [38] Effects of hippocampal histone acetylation and HDAC inhibition on spatial learning and memory in the Morris water maze in rats
    Topuz, Ruhan Deniz
    Gunduz, Ozgur
    Tastekin, Ebru
    Karadag, Cetin Hakan
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020, 34 (02) : 222 - 228
  • [39] Postsynaptic bk channels promote schaffer collateral LTP and hippocampal memory formation in The Morris Water Maze
    Pham, T.
    Bischof, H.
    Simonsig, S.
    Kalina, D.
    Ehinger, R.
    Ruth, P.
    Lukowski, R.
    Matt, L.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2021, 394 (SUPPL 1) : S46 - S46
  • [40] Changes of hippocampal β-alanine and citrulline levels parallel early and late phase of retrieval in the Morris Water Maze
    Sase, Ajinkya
    Dahanayaka, Sudath
    Hoeger, Harald
    Wu, Guoyao
    Lubec, Gert
    AMINO ACIDS, 2013, 45 (03) : 564 - 564
12345