Bilateral and unilateral hippocampal inactivation did not differ in their effect on consolidation processes in the Morris water maze

被引：9
|
作者：
Cimadevilla, Jose M. [1 ]
Miranda, Ruben [2 ]
Lopez, Laudino [3 ]
Arias, Jorge L. [3 ]
机构：
[1] Univ Almeria, Dept Neurosci, Almeria 04007, Spain
[2] Univ Baleares, Dept Psychol, Palma De Mallorca, Spain
[3] Univ Oviedo, Dept Psychol, Oveido, Spain
来源：
INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2008年 / 118卷 / 05期
关键词：
acquisition; navigation; rat; retrieval; spatial memory; TTX;
D O I：
10.1080/00207450701242818
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Consolidation processes were studied in the rat by using functional inactivation techniques. Previous results showed that unilateral hippocampal inactivation alters consolidation. It is not clear if bilateral treatments increase the impairment. Wistar rats were trained in the Morris water maze during 4 consecutive days. Subjects received saline or tetrodotoxin in the dorsal hippocampus 1 min after training. Results showed that bilateral as well as unilateral treatments impair consolidation to the same degree, as shown by the mean latency to reach the platform. In both cases, the impairment is only visible in the first trial of the session following the blockade.
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页码：619 / 626
页数：8
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