Asymmetric organocatalytic three-component 1,3-dipolar cycloaddition: Control of stereochemistry via a chiral bronsted acid activated dipole

被引：238
|
作者：
Chen, Xiao-Hua [1 ,2 ,3 ]
Zhang, Wen-Quan [1 ,2 ]
Gong, Liu-Zhu [1 ,2 ,3 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China
[3] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 17期
关键词：
D O I：
10.1021/ja801034e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Bronsted acid catalyzed three-component asymmetric 1,3-dipolar addition reaction between aldehydes, amino esters, and dipolarophiles by a new bisphosphoric acid, derived from the linked BINOL, furnished multiply substituted pyrrolidines in high yield with excellent enantioselectivities under mild conditions.
引用
收藏
页码：5652 / +
页数：3
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