Three-component procedure for the synthesis of new chiral spirooxindolopyrrolizidines via catalytic highly enantioselective 1,3-dipolar cycloaddition

被引：0
|
作者：
Taghizadeh, Mohammad Javad [1 ]
Jadidi, Khosrow [2 ]
Javidan, Abdollah [1 ]
机构：
[1] Univ Imam Hossein, Sch Sci, Dept Chem, Tehran, Iran
[2] Shahid Beheshti Univ, GC, Dept Chem, Tehran 1983963113, Iran
来源：
IRANIAN CHEMICAL COMMUNICATION | 2015年 / 3卷 / 02期
关键词：
Chiral auxiliaries; chiral spiro-oxindolopyrrolizidines; asymmetric 1,3-dipolar; azomethineylide; three-component reaction; MCRs; proline; sarcosine;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The catalytic highly regio-, diastereo-, and enantioselective synthesis of a small library of spiropyrrolizidineoxindoles via a four-component 1,3-dipolar cycloaddition reaction of azomethine ylides, derived from isatin, with electron-deficient dipolarophile was described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendatebis(imine)-Cu(II) triflate complex as efficient catalyst.
引用
收藏
页码：114 / 124
页数：11
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