Risk factors of fever after endoscopic submucosal dissection of gastrointestinal tumors

Aim: This study aims to identify the risk factors of fever after endoscopic submucosal dissection (ESD) of gastrointestinal tumors and the value of the highest body temperature within 24 hours (T-max) after ESD to predict postoperative complications of ESD. Material/Methods: A retrospective study was performed on 100 patients of ESD in our hospital from December 2012 to December 2015. Two patients were excluded for not meeting the inclusion criteria. Based on whether the patients had postoperative fever (T >= 38.0 degrees C), they were divided into two groups. Results: Between fever group (n = 33) and no fever group (n = 65), there was no significant difference in basic characteristics, gross type, postoperative hospital stay and cost. The operation time was longer in fever group than no fever group (respectively, 124 min vs 86 min, P < 0.05). The mean resected specimen size was larger in fever group than no fever group [respectively, 4.0 cm (range 1.2-10.0 cm) vs 1.9 cm, (range 1.0-6.5 cm), P < 0.05]. The complication rate was higher in fever group than no fever group (respectively, 39.4% vs 4.6%, P < 0.05). The multivariate logistic regression suggested that the resected specimen size (OR = 1.797, 95% CI = 1.174-2.750, P < 0.05) was an independent risk factor for fever after ESD. The AUC of T-max after ESD for postoperative complications of ESD was 0.845. Conclusions: The ESD resected specimen size (>= 2.70 cm) is an independent risk factor of fever after ESD. T-max (>= 38.0 degrees C) after ESD could be a predictor of postoperative complications of ESD.