Analysis of KIR ligand incompatibility in human renal transplantation

被引：42
|
作者：
Tran, TH
Mytilineos, J
Scherer, S
Laux, G
Middleton, D
Opelz, G
机构：
[1] Univ Heidelberg, Inst Immunol, Dept Transplantat Immunol, D-69120 Heidelberg, Germany
[2] City Hosp, No Ireland Histocompatibil & Immunogenet Lab, Belfast, Antrim, North Ireland
来源：
TRANSPLANTATION | 2005年 / 80卷 / 08期
关键词：
natural killer cells; killer immunoglobulin-like receptors; major histocompatibility complex; renal transplantation; graft survival;
D O I：
10.1097/01.tp.0000179110.15304.90
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer cells express killer immunoglobulin-like receptors (KIR) that bind to MHC class I antigens. Lack of self-MHC on the target cell can cause NK-cell mediated killing. Here, we analyzed the effect of KIR ligand incompatiblity on renal allograft survival in humans. Kidney recipient/donor pairs were separated according to their HLA-Cw alleles and HLA-Bw4 specificity which are considered epitopes for KIR. A total of 2,757 renal transplants were examined. Graft survival rates were computed according to the Kaplan-Meier method. No effect of KIR ligand matching on graft survival was observed in cadaver kidney transplants. Our results indicate that KIR ligand matching cannot be recommended as a strategy for improving renal allograft survival.
引用
收藏
页码：1121 / 1123
页数：3
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