Transforming growth factor-beta receptor signaling in cancer

被引：19
|
作者：
Narayan, S
Thangasamy, T
Balusu, R
机构：
[1] Univ Florida, Coll Med, UF Shands Canc Ctr, Gainesville, FL 32610 USA
[2] Univ Florida, Dept Anat & Cell Biol, Gainesville, FL 32610 USA
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2005年 / 10卷
关键词：
apoptosis; ligands; receptors; ski; I-Smads; Smads; transforming growth factor beta; tumor suppressor;
D O I：
10.2741/1606
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transforming growth factor-beta (TGF-beta) is an ubiquitous cytokine that affects various biological processes, such as regulation of cell proliferation, immune responses, growth, differentiation, angiogenesis, and apoptosis of various cell types. The TGF-beta ligand initiates signaling by binding to and joining type I and II receptors of serine/threonine kinases. This review discusses the TGF-beta ligands and receptors, its positive and negative regulators in signaling, as well as its important roles with respect to tumor suppression and progression.
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页码：1135 / 1145
页数：11
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