Anti-Apoptosis Effects on Hearts of SHSST Cyclodextrin Complex in a Carbon Tetrachloride-Induced Cirrhotic Cardiomyopathy Rat Model

被引:2
|
作者
Yang, Cheng-Hsun [1 ,2 ]
Ting, Wei-Jen [3 ]
Pai, Pei-Ying [4 ,5 ]
Chang, Sheng-Huang [6 ]
Ho, Tsung-Jung [2 ,7 ]
Lin, Jing-Ying [8 ]
Tsai, Fuu-Jen [2 ]
Padama, Viswanadha Vijaya [9 ]
Tsai, Yuhsin [1 ,2 ]
Huang, Chih-Yang [2 ,3 ,10 ]
机构
[1] China Med Univ, Grad Inst Chinese Med, Taichung 40402, Taiwan
[2] China Med Univ, Sch Chinese Med, Taichung 40402, Taiwan
[3] China Med Univ, Grad Inst Basic Med Sci, Taichung 40402, Taiwan
[4] China Med Univ Hosp, Div Cardiol, Taichung 40402, Taiwan
[5] China Med Univ, Grad Inst Clin Med Sci, Taichung 40402, Taiwan
[6] Minist Hlth & Welf, Tsaotun Psychiat Ctr, Dept Lab, Nantou 54249, Taiwan
[7] China Med Univ, Beigang Hosp, Chinese Med Dept, Yunlin 63244, Taiwan
[8] Cent Taiwan Univ Sci & Technol, Dept Med Imaging & Radiol Sci, Taichung 40601, Taiwan
[9] Bharathiar Univ, Dept Biotechnol, Coimbatore 641046, Tamil Nadu, India
[10] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 41354, Taiwan
来源
CHINESE JOURNAL OF PHYSIOLOGY | 2015年 / 58卷 / 01期
关键词
baicalein; beta-cyclodextrin modified SHSST; cirrhotic cardiomyopathy; silymarin; EXTRACT; INHIBITION; PREVENTS; DELIVERY; PATHWAY; CELLS;
D O I
10.4077/CJP.2015.BAD286
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Cirrhotic cardiomyopathy (CCM) is a common cardiac dysfunction in patients waiting for orthotopic liver transplantation (OLT). Carbon tetrachloride (CCI4) intraperitoneal (IF) injection has been reported as successful in a cirrhosis-induced CCM model. In this work, we used the same assay for CCM induction using CCI4 (0.2 mg/kg) IP injection twice per day for 14 days during the cardiac protection drugs treatment process. The cardiac protection drugs were silymarin (100 mg/kg/day), baicalein (30 mg/kg/day), San Huang Shel Shin Tang (SHSST, 30 mg/kg/day) and beta-cyclodextrin modified SHSST (SHSSTc, 30 mg/kg/day and 300 mg/kg/day). After 4 weeks of treatment, the SHSSTc cardiac protection effects were determined through activation of the IGF1R cell survival pathway and inhibition of Fas-FADD death domain induced-apoptosis. SHSSTc cardiac protection was enhanced through beta-cyclodextrin modification, which increased bio-availability, and displayed stronger protective effects than silymarin and baicalein, both of which are well-known liver protection drugs. Thus, SHSSTc might provide the best therapeutic benefit in CCM treatment.
引用
收藏
页码:38 / 45
页数:8
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