Effusion cytomorphology of small round cell tumors

被引:11
|
作者
Ikeda, Katsuhide [1 ]
Tsuta, Koji [1 ,2 ]
机构
[1] Natl Canc Ctr, Dept Clin Lab, Tokyo, Japan
[2] Kansai Med Univ, Dept Pathol & Clin Lab, Osaka, Japan
关键词
Cytology; effusion; small round cell tumors (SRCTs); ALVEOLAR RHABDOMYOSARCOMA; DIAGNOSIS; CYTOLOGY;
D O I
10.4103/0970-9371.182529
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: Small round cell tumors (SRCTs) are a group of tumors composed of small, round, and uniform cells with high nuclear/cytoplasmic (N/C) ratios. The appearance of SRCT neoplastic cells in the effusion fluid is very rare. We reported the cytomorphological findings of SRCTs in effusion cytology, and performed statistical and mathematical analyses for a purpose to distinguish SRCTs. Materials and Methods: We analyzed the cytologic findings of effusion samples from 40 SRCT cases and measured the lengths of the nuclei, cytoplasms, and the cell cluster areas. The SRCT cases included 14 Ewing sarcoma (EWS)/primitive neuroectodermal tumor cases, 5 synovial sarcoma cases, 6 rhabdomyosarcoma cases, 9 small cell lung carcinoma (SCLC) cases, and 6 diffuse large B-cell lymphoma (DLBL) cases. Results: Morphologically, there were no significant differences in the nuclear and cytoplasmic lengths in cases of EWS, synovial sarcoma, and rhabdomyosarcoma. The cytoplasmic lengths in cases of SCLC and DLBL were smaller than those of EWS, synovial sarcoma, and rhabdomyosarcoma. The nuclear density of the cluster in SCLC was higher than that in other SRCTs, and cases of DLBL showed a lack of anisokaryosis and anisocytosis. Conclusion: We believe that it might be possible to diagnose DLBL and SCLC from cytologic analysis of effusion samples but it is very difficult to use this method to distinguish EWS, synovial sarcoma, and rhabdomyosarcoma. Statistical and mathematical analyses indicated that nuclear density and dispersion of nuclear and cytoplasmic sizes are useful adjuncts to conventional cytologic diagnostic criteria, which are acquired from experience.
引用
收藏
页码:85 / 92
页数:8
相关论文
共 50 条
  • [41] Soft tissue small round cell tumors: Morphological parameters
    dAmore, ESG
    Ninfo, V
    SEMINARS IN DIAGNOSTIC PATHOLOGY, 1996, 13 (03) : 184 - 203
  • [42] Diagnosis and classification of small round-cell tumors of childhood
    Ladanyi, M
    AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (06): : 2181 - 2182
  • [43] NMYC PROTEIN EXPRESSION IN SMALL ROUND CELL TUMORS OF CHILDHOOD
    TRICHE, TJ
    REYNOLDS, CP
    SLAMON, DJ
    SEEGER, RC
    LABORATORY INVESTIGATION, 1987, 56 (01) : A79 - A79
  • [44] CD31 immunoreactivity in small round cell tumors
    Nicholson, SA
    McDermott, MB
    DeYoung, BR
    Swanson, PE
    APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2000, 8 (01): : 19 - 24
  • [45] Clinicopathologic Features of Intracranial Desmoplastic Small Round Cell Tumors
    Lee, Julieann
    Ferris, Sean
    Cham, Elaine
    Gilani, Ahmed
    Kleinschmidt-DeMasters, Bette
    Trembath, Dimitri
    Mafra, Manuela
    Chiang, Cheng-Hsuan
    Ellison, David
    Solomon, David
    Perry, Arie
    MODERN PATHOLOGY, 2019, 32
  • [46] Diagnosis and classification of the small round-cell tumors of childhood
    Cohn, SL
    AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (01): : 11 - 15
  • [47] Results of multimodal treatment for desmoplastic small round cell tumors
    Lal, DR
    Su, WT
    Wolden, SL
    Loh, KC
    Modak, S
    La Quaglia, MP
    JOURNAL OF PEDIATRIC SURGERY, 2005, 40 (01) : 251 - 255
  • [48] Primary Small Blue Round Cell Tumors of The Breast in Adolescents
    De Machaj, Z.
    Lezama-Del Valle, P.
    Espino Duran, M.
    PEDIATRIC BLOOD & CANCER, 2021, 68 : S315 - S316
  • [49] CD31 immunoreactivity in small round cell tumors
    Nicholson, S
    McDermott, MB
    Swanson, PE
    De Young, BR
    LABORATORY INVESTIGATION, 1998, 78 (01) : 13A - 13A
  • [50] CYTOGENETIC CHARACTERIZATION OF SELECTED SMALL ROUND CELL TUMORS OF CHILDHOOD
    WHANGPENG, J
    TRICHE, TJ
    KNUTSEN, T
    MISER, J
    KAOSHAN, S
    TSAI, S
    ISRAEL, MA
    CANCER GENETICS AND CYTOGENETICS, 1986, 21 (03) : 185 - 208