Advances in Mitochondrial Ultrastructure and Its Regulatory Mechanism

被引：0
|
作者：
Huang Guo-Min [1 ,2 ,3 ,4 ]
Wang Yu-Pei [5 ]
Sun Chao [1 ,2 ,3 ,4 ]
Zhang Xue-Tian [1 ,2 ,3 ,4 ]
Zhang Hong [1 ,2 ,3 ,4 ]
机构：
[1] Univ Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China
[4] Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China
[5] Gansu Prov Maternal & Child Hlth Care Ctr, Lanzhou 730000, Gansu, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2019年 / 46卷 / 12期
关键词：
mitochondria; ultrastructure; Crista junction; MICOS; F1F0-ATP synthase; DOMINANT OPTIC ATROPHY; CONTACT SITE; COMPLEX I; MEMBRANE ARCHITECTURE; PARKINSONS-DISEASE; ORGANIZING SYSTEM; CALCIUM UNIPORTER; CA2+ UNIPORTER; BARTH SYNDROME; ATP SYNTHASE;
D O I：
10.16476/j.pibb.2019.0142
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondrial ultrastructure is a fine structure observed by electron microscope, which can be changed according to different energy requirements and physiological environment, and plays a key role in regulating mitochondrial function. The structure of mitochondrial cristae is an important mitochondrial ultrastructure, which affects many mitochondrial diseases. Therefore, studying the function and understanding the regulation mechanism of mitochondrial ultrastructure have important guiding significance for studying mitochondrial diseases and looking for therapeutic targets. This paper introduces the main regulating mechanism of mitochondrial cristae in detail, and focuses on the research progress in the composition of mitochondrial ultrastructure, the effect of mitochondrial ultrastructure on mitochondrial function, and the relationship between mitochondrial ultrastructure and mitochondrial disease, in order to provide theoretical reference for developing more effective mitochondrial disease treatment.
引用
收藏
页码：1141 / 1149
页数：9
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