Different Immunoregulation Roles of Activin A Compared With TGF-β

被引：16
|
作者：
Li, Fanglin [1 ,2 ]
Long, Yiru [1 ,2 ]
Yu, Xiaolu [1 ,2 ]
Tong, Yongliang [1 ,2 ]
Gong, Likun [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
[3] Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词：
activin A; TGF-beta; activin A signaling; macrophages; dendritic cells; B cells; T effector cells; regulatory T cells; GROWTH-FACTOR-BETA; REGULATORY T-CELLS; MACROPHAGES IN-VITRO; AUTOIMMUNE NEUROINFLAMMATION; ACTIVATION; CYTOKINE; SUPERFAMILY; TGF-BETA-1; PATHOGENICITY; MATURATION;
D O I：
10.3389/fimmu.2022.921366
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Activin A, a critical member of the transforming growth factor-beta (TGF-beta) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-beta, activin A also transmits signals through SMAD2/SMAD3, however, they bind to distinct receptors. Recent studies have uncovered that activin A plays a pivotal role in both innate and adaptive immune systems. Here we mainly focus its effects on activation, differentiation, proliferation and function of cells which are indispensable in the immune system and meanwhile make some comparisons with those of TGF-beta.
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页数：9
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