Endobronchial combined treatment of non-small cell lung cancer

From 1990 to 1995 48 patients (pts) with non-small cell lung cancer (NSCLC) underwent combined treatment using endobronchial intratumoral bleomicine (BL) injections during irradiation with dynamic fractions (RDF). Weekly schedule of fractions was 4-2-2-2-4 Gy, and twice: a meek we installed to the tumour 15-30.0 mg of BL. Summary dosage of BL ranged between 90.0 mg and 150.0 mg, and 65 Gy of RDF. Partial rapid tumour response was achieved in 32(66,7%) cases, and in 6(12,5%) cases there was complete response, in 10(20,8%) cases me had no tumour ,oi response. In 1992-1995 16 patients with NSCLC underwent photodynamic therapy (PDT) with haematoparphyrin A and metal vapour 630 nm wave length laser beam and conventional RT up to 40 Gy. We injected 5 mg/kg of photosensitizer (haematoporphyrin A) and used 3 times a week 30 minutes laser beam applications to bronchus tumours. Partial tumour response in 8 (50%)pts and no complete response were achieved. All these pts were randomised with control groups.