Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria

被引：9

作者：

Otieno, Steve Biko ^{[1
,2
,3
]}

Altahan, Alaa ^{[1
,2
,3
]}

Kaweeta, Fnu ^{[1
]}

Karri, Saradasri ^{[1
,2
,3
]}

Alnoor, Fnu ^{[2
,4
]}

Johnson, Robert ^{[3
]}

机构：

[1] Univ Tennessee, Hlth Sci Ctr, Dept Hematol & Oncol, 19 S Manassas, Memphis, TN 38103 USA

[2] Vet Affairs Med Ctr, 1030 Jefferson Ave, Memphis, TN 38104 USA

[3] West Canc & Res Inst, 7945 Wolf River Blvd, Germantown, TN 38138 USA

[4] Univ Tennessee, Hlth Sci Ctr, Dept Pathol, 930 Madison Ave, Memphis, TN 38103 USA

来源：

CASE REPORTS IN HEMATOLOGY | 2021年 / 2021卷

关键词：

D O I：

10.1155/2021/6619177

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. We report a case of a patient who presented with fatigue, facial swelling, and upper respiratory infection (URI) symptoms and was found to have COVID-19 with laboratory tests showing severe hemolysis and pancytopenia secondary to PNH.

引用

页数：6

共 50 条

[21] Oxidative Stress and Intravascular Hemolysis in Paroxysmal Nocturnal Hemoglobinuria
Osato, Makiko
Nishimura, Jun-ichi
Motoki, Yukari
Hayashi, Satoru
Ueda, Yasutaka
Nojima, Junzo
Kanakura, Yuzuru
BLOOD, 2014, 124 (21)
[22] Significant hemolysis is not required for thrombosis in paroxysmal nocturnal hemoglobinuria
Griffin, Morag
Hillmen, Peter
Munir, Talha
Richards, Stephen
Arnold, Louise
Riley, Kathryn
Hill, Anita
HAEMATOLOGICA, 2019, 104 (03) : E94 - E96
[23] The Course of COVID-19 in a Patient with Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria Clone: A Case Report and Literature Review
Sasi, Sreethish
Yassin, Mohamed A.
Nair, Arun P.
Fadul, Afraa M.
Abukhattab, Mohammed A.
DUBAI MEDICAL JOURNAL, 2021, 4 (03): : 235 - 238
[24] PREGNANCY IN A PATIENT WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
FRAKES, JT
BURMEISTER, RE
GILIBERTI, JJ
OBSTETRICS AND GYNECOLOGY, 1976, 47 (01): : S22 - S24
[25] COVID19 infection in a patient undergoing treatment for Paroxysmal Nocturnal Hemoglobinuria (PNH) with Ravulizumab
Shikdar, Sufana
Borogovac, Azra
Mohamad, Elabdallah
Khawandanah, Mohamad
THROMBOSIS JOURNAL, 2021, 19 (01)
[26] COVID19 infection in a patient undergoing treatment for Paroxysmal Nocturnal Hemoglobinuria (PNH) with Ravulizumab
Sufana Shikdar
Azra Borogovac
Elabdallah Mohamad
Mohamad Khawandanah
Thrombosis Journal, 19
[27] Lactic acidosis secondary to severe anemia in a patient with paroxysmal nocturnal hemoglobinuria
Essex, DW
Jin, DK
Bradley, TP
AMERICAN JOURNAL OF HEMATOLOGY, 1997, 55 (02) : 110 - 111
[28] PAROXYSMAL NOCTURNAL HEMOGLOBINURIA . MECHANISM OF ENHANCEMENT OF HEMOLYSIS BY BOVINE THROMBIN
BLUM, SF
GARDNER, FH
BLOOD-THE JOURNAL OF HEMATOLOGY, 1967, 30 (03): : 352 - &
[29] Ineffective Corticosteroid Treatment for Hemolysis Management of Paroxysmal Nocturnal Hemoglobinuria
Lee, Jong Wook
Jang, Jun Ho
Lee, Je-Hwan
Jo, Deog-Yeon
Kim, Jin Seok
Park, Yong
Sohn, Sang Kyun
Park, Jun Sung
Choi, Chul Won
Chung, Joo Seop
Lee, Jae Hoon
Kim, Jeong A.
Won, Jong-Ho
BLOOD, 2014, 124 (21)
[30] ROLE OF CALCIUM IN "PAROXYSMAL-NOCTURNAL-HEMOGLOBINURIA HEMOLYSIS - REPLY
MAY, JE
ROSSE, W
FRANK, MM
NEW ENGLAND JOURNAL OF MEDICINE, 1973, 289 (24): : 1314 - 1314

← 1 2 3 4 5 →