Redox-Neutral Generation of Iminyl Radicals by N-Heterocyclic Carbene Catalysis: Rapid Access to Phenanthridines from Vinyl Azides

被引：0

作者：

Liu, Lixia ^{[1
]}

Zhang, Qijing ^{[1
]}

Wang, Chengming ^{[1
]}

机构：

[1] Jinan Univ, Coll Chem & Mat Sci, Guangdong Prov Key Lab Funct Supramol Coordinat Ma, Guangzhou 511443, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2022年

关键词：

CYCLIZATION;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An N-heterocyclic carbene-catalyzed oxidant-, metal-and light-free iminyl radical generation pathway stemming from the reaction of vinyl azide and alpha-bromo ester is uncovered. This newly developed methodology is successfully applied to the redox-neutral construction of a number of diversified phenanthridine derivatives with nice functional group compatibility. Insights from the mechanism study reveal that this NHC-catalyzed transformation potentially proceeds through an alkyl radical addition-initiated HAS process, with the iminyl radical as an active intermediate.

引用

页数：5

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