Traceless solid phase synthesis of 2,3-disubstituted indoles

被引：82
|
作者：
Smith, AL [1 ]
Stevenson, GI [1 ]
Swain, CJ [1 ]
Castro, JL [1 ]
机构：
[1] Merck Sharp & Dohme Res Labs, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 45期
关键词：
D O I：
10.1016/S0040-4039(98)01824-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the traceless solid phase synthesis of 2,3-disubstituted indoles using a THP linker and a Pd(0)-mediated annulation of 2-iodoaniline and acetylenes is reported. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：8317 / 8320
页数：4
相关论文
共 50 条
  • [21] Synthesis of 2,3-disubstituted benzofurans on solid-support
    Jung, Chun-Won
    Shen, Liu-Lan
    Choi, Brian Hyun
    Kwak, Young-Shin
    Jeong, Jin-Hyun
    TETRAHEDRON LETTERS, 2010, 51 (50) : 6588 - 6589
  • [22] Synthesis of 3,3-Disubstituted Indolenines Utilizing the Lewis Acid Catalyzed Alkylation of 2,3-Disubstituted Indoles with Trichloroacetimidates
    Adhikari, Arijit A.
    Radal, Lea
    Chisholm, John D.
    SYNLETT, 2017, 28 (17) : 2335 - 2339
  • [23] Iodine-Mediated α-Acetoxylation of 2,3-Disubstituted Indoles
    Zaimoku, Hisaaki
    Hatta, Takashi
    Taniguchi, Tsuyoshi
    Ishibashi, Hiroyuki
    ORGANIC LETTERS, 2012, 14 (23) : 6088 - 6091
  • [24] Synthesis of 2,3-disubstituted norbornadienes
    Tranmer, GK
    Yip, C
    Handerson, S
    Jordan, RW
    Tam, W
    CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 2000, 78 (05): : 527 - 535
  • [25] SYNTHESIS OF 2,3-DISUBSTITUTED QUINOLINES
    MAGNIN, AA
    STEPHEN, AM
    JOURNAL OF THE SOUTH AFRICAN CHEMICAL INSTITUTE, 1971, 24 (NSEP): : 238 - &
  • [26] Palladium-catalyzed β-allylation of 2,3-disubstituted indoles
    Kagawa, Natsuko
    Malerich, Jeremiah P.
    Rawal, Viresh H.
    ORGANIC LETTERS, 2008, 10 (12) : 2381 - 2384
  • [27] Synthesis of 2,3-disubstituted quinoxalines
    Barot, VM
    Modi, SR
    Naik, HB
    ASIAN JOURNAL OF CHEMISTRY, 1999, 11 (03) : 1032 - 1033
  • [28] SYNTHESIS OF 2,3-DISUBSTITUTED SUCCINODINITRILES
    WHITELEY, RV
    MARIANELLI, RS
    SYNTHESIS-STUTTGART, 1978, (05): : 392 - 394
  • [29] THE SYNTHESIS OF PROPELLANE COMPOUNDS FROM 2,3-DISUBSTITUTED INDOLES AND ORTHO-BENZOQUINONES
    OMOTE, Y
    HARADA, K
    TOMOTAKE, A
    KASHIMA, C
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1984, 21 (06) : 1841 - 1844
  • [30] Rearrangement of 3,3-disubstituted indolenines and synthesis of 2,3-substituted indoles
    Liu, Kevin G.
    Robichaud, Albert J.
    Lo, Jennifer R.
    Mattes, James F.
    Cai, Yanxuan
    ORGANIC LETTERS, 2006, 8 (25) : 5769 - 5771
12345