Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ)

被引：91

作者：

Ristow, Oliver ^{[1
,2
]}

Otto, Sven ^{[3
]}

Troeltzsch, Matthias ^{[3
]}

Hohlweg-Majert, Bettina ^{[2
,4
]}

Pautke, Christoph ^{[2
,3
]}

机构：

[1] Heidelberg Univ, Dept Oral & Maxillofacial Surg, D-69120 Heidelberg, Germany

[2] Clin Oral & Maxillofacial & Plast Surg, D-80333 Munich, Germany

[3] Univ Munich, Dept Oral & Maxillofacial Surg, D-80336 Munich, Germany

[4] Tech Univ Munich, Dept Oral & Maxillofacial Surg, D-81675 Munich, Germany

来源：

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | 2015年 / 43卷 / 02期

关键词：

Bisphosphonate; Denosumab; Osteonecrosis of the jaw; BRONJ; Surgical treatment; Fluorescence-guided bone resection; BISPHOSPHONATE-RELATED OSTEONECROSIS; GUIDED BONE RESECTION; RISK-FACTORS; FOLLOW-UP; SURGICAL RESECTION; MULTIPLE-MYELOMA; CANCER-PATIENTS; CASE SERIES; FLUORESCENCE; MANAGEMENT;

D O I：

10.1016/j.jcms.2014.11.014

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The medication-related osteonecrosis of the jaw (MRONJ) is believed to be a therapy-resistant entity. Although the application of the recommended conservative and surgical treatment regimens have returned variable success rates, the increased awareness and experience with MRONJ suggests that surgical therapy can halt the progression of the disease, thereby allowing a histology-based diagnosis of the osteonecrosis. Surgical treatment protocols can achieve success rates of over 90% and novel techniques such as the visualization of bone fluorescence can assist in the intra-operative delineation of the osteonecrosis and standardize the procedure. (C) 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

引用

页码：290 / 293

页数：4

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