The relationship between glycosylated haemoglobin (HbA1c) and measures of insulin resistance across a range of glucose tolerance

被引：51
|
作者：
Borai, Anwar [1 ,2 ]
Livingstone, Callum [2 ,3 ]
Abdelaal, Fatima [1 ]
Bawazeer, Ali [1 ]
Keti, Vuyolethu [2 ]
Ferns, Gordon [2 ,3 ]
机构：
[1] King Khalid Natl Guard Hosp, Dept Pathol, Jeddah 21423, Saudi Arabia
[2] Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 5XH, Surrey, England
[3] Royal Surrey Cty Hosp, Dept Clin Biochem, Guildford, Surrey, England
来源：
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2011年 / 71卷 / 02期
关键词：
FSIVGTT; HOMA; ISI-gly; OGTT; QUICKI; minimal model; METABOLIC SYNDROME; SENSITIVITY; INDEXES; PREDICTOR; SURROGATE; CLAMP;
D O I：
10.3109/00365513.2010.547947
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim. This study aimed to assess the correlation between HbA1c and insulin resistance as measured by a variety of different indices in subjects from across the glycaemic spectrum. Methods. Subjects with normal glucose tolerance (NGT; n = 24), impaired fasting glucose (IFG; n = 12), impaired glucose tolerance (IGT; n = 12), and type 2 diabetes (DM; n = 13) were studied. All had specimens taken in the context of a standard oral glucose tolerance test at their first visit and had the insulin sensitivity parameter (Si) determined by frequently-sampled intravenous glucose tolerance test at a second visit. Results. HbA1c was more strongly associated with Si in NGT (r = - 0.65) than in IFG (r = - 0.48). Compared to other indices of insulin resistance HbA1c has minimal overlap in values (0.0%) between NGT and subjects with type 2 diabetes. Conclusions. HbA1c can be used as a simple and reliable marker of insulin resistance in NGT adults with relatively high insulin sensitivity.
引用
收藏
页码：168 / 172
页数：5
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