Synthesis and antifungal activity of 3-substituted 5-ferrocenyl-1H-pyrazoles

被引：4
|
作者：
Ge, Man [1 ,2 ]
Huang, Hailian [1 ]
Gou, Xiaofeng [1 ]
Hua, Chengwen [1 ]
Chen, Bang [1 ]
Zhao, Junlong [1 ]
机构：
[1] Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, 1 Xuefu Ave, Xian 710127, Shaanxi, Peoples R China
[2] Xian Univ Architecture & Technol, Coll Sci, 13 Yanta Rd, Xian 710055, Shaanxi, Peoples R China
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 10期
基金：
中国国家自然科学基金;
关键词：
ferrocene; iron(III) phthalocyanine chloride; pyrazole; antifungal activity; BIOLOGICAL-ACTIVITY; PYRAZOLE DERIVATIVES; EFFICIENT SYNTHESIS; FERROCENE; DESIGN; APOPTOSIS; FACILE; BASES; DNA;
D O I：
10.1007/s10593-018-2379-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient method for the selective synthesis of functionalized 3-substituted 5-ferrocenyl-1H-pyrazoles has been developed. Condensation reaction of a, beta-unsaturated ferrocenyl ketones and tosylhydrazine in the presence of catalytic amount of iron(III) phthalocyanine chloride allowed to obtain nine new 3-substituted 5-ferrocenyl-1H-pyrazoles. The synthesized products were evaluated for their antifungal activity against Gibberella nicotiancola, Fusarium oxysporum f. sp. niveum, and Gibberella saubinetii. Most of the compounds exhibited excellent antifungal activity.
引用
收藏
页码：951 / 955
页数：5
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