Copper-catalyzed arylation of heterocycle C-H bonds

被引：456
|
作者：
Do, Hien-Quang [1 ]
Daugulis, Olafs [1 ]
机构：
[1] Univ Houston, Dept Chem, Houston, TX 77204 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 41期
关键词：
D O I：
10.1021/ja075802+
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new method for the direct, copper-catalyzed arylation of heterocycle C-H bonds by aryl halides has been developed. In addition to electron-rich five-membered heterocycles, electron-poor pyridine oxides can also be arylated. The best results are obtained by using a combination of lithium tert -butoxide base, aryl iodide coupling partner, and copper iodide catalyst.
引用
收藏
页码：12404 / +
页数：3
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