RESISTANCE TO EGFR INHIBITION VIA THE EMERGENCE OF EGFRVIII-INDEPENDENT TUMOR GROWTH-PROMOTING MECHANISMS IN GLIOBLASTOMA

被引:0
|
作者
Wykosky, Jill [1 ]
Mukasa, Akitake [2 ]
Chin, Lynda [3 ]
Cavenee, Webster [1 ]
Furnari, Frank [1 ]
机构
[1] Ludwig Inst Canc Res, New York, NY USA
[2] Univ Tokyo, Tokyo 1138654, Japan
[3] Dana Farber Canc Inst, Boston, MA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:21 / 21
页数:1
相关论文
共 50 条
  • [41] Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2
    Smith, Bryan D.
    Kaufman, Michael D.
    Leary, Cynthia B.
    Turner, Benjamin A.
    Wise, Scott C.
    Ahn, Yu Mi
    Booth, R. John
    Caldwell, Timothy M.
    Ensinger, Carol L.
    Hood, Molly M.
    Lu, Wei-Ping
    Patt, Tristan W.
    Patt, William C.
    Rutkoski, Thomas J.
    Samarakoon, Thiwanka
    Telikepalli, Hanumaiah
    Vogeti, Lakshminarayana
    Vogeti, Subha
    Yates, Karen M.
    Chun, Lawrence
    Stewart, Lance J.
    Clare, Michael
    Flynn, Daniel L.
    MOLECULAR CANCER THERAPEUTICS, 2015, 14 (09) : 2023 - 2034
  • [42] CD27 signaling inhibits tumor growth and metastasis via CD8+T cell-independent mechanisms in the B16-F10 melanoma model
    Puppala, Eswara Rao
    Wu, Long
    Fan, Xiaoxuan
    Cao, Xuefang
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2024, 73 (10)
  • [43] Knockdown of DCAMKL-1 Results in liver Cancer Tumor Growth Arrest Through Inhibition of c-MYC via Let-7a MicroRNA; Inhibits EMT via Mir-200a MicroRNA Dependent Mechanisms
    Sureban, Sripathi N.
    Qu, Dongleng
    May, Randal
    Asfa, Sima
    Anant, Shrikant
    Houchen, Courtney W.
    GASTROENTEROLOGY, 2011, 140 (05) : S890 - S890
  • [44] Combination epidermal growth factor receptor (EGFR) tyrosine kinase and cyclooxygenase-2 (COX-2) inhibition decreases cell growth in vitro and in vivo in non-small cell lung cancer (NSCLC): Two independent pathways regulate COX-2 dependent EGFR tyrosine kinase inhibitor resistance in NSCLC.
    Reckamp, Karen L.
    Zhang, Ling
    Yang, Seok Chul
    Dohadwala, Mariam
    Krysan, Kostyantyn
    Zhu, Li
    Sharma, Sherven
    Dubinett, Steven M.
    CANCER RESEARCH, 2006, 66 (08)
  • [45] Synergistic and selective inhibition of NSCLC cell growth via a caspase-independent cell death pathway by tumor suppressor 101F6 nanoparticles plus vitamin C in vitro and in vivo.
    Ohtani, Shoichiro
    Ueda, Kentaro
    Jayachandran, Gitanjali
    Xu, Kai
    Minna, John D.
    Roth, Jack A.
    Ji, Lin
    CANCER RESEARCH, 2006, 66 (08)
  • [46] LIGAND-DEPENDENT ACTIVATION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INDUCES EARLY DRUG RESISTANCE IN BRAIN TUMOR CELLS VIA ACTIVATION OF ITS DOWNSTREAM TARGET GLUTATHIONE S-TRANSFERASE P1
    Okamura, Tatsunori
    Singh, Simendra
    Bigner, Darell
    Ali-Osman, Francis
    NEURO-ONCOLOGY, 2008, 10 (05) : 782 - 782
  • [47] Synergistic Inhibition of Drug-Resistant Colon Cancer Growth with PI3K/mTOR Dual Inhibitor BEZ235 and Nano-Emulsioned Paclitaxel via Reducing Multidrug Resistance and Promoting Apoptosis
    Hu, Yali
    Zhang, Kunpeng
    Zhu, Xingyao
    Zheng, Xiuyan
    Wang, Chao
    Niu, Xiao
    Jiang, Teng
    Ji, Xinhua
    Zhao, Weilin
    Pang, Lijuan
    Qi, Yan
    Li, Feng
    Li, Li
    Xu, Zhiping
    Gu, Wenyi
    Zou, Hong
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021, 16 : 2173 - 2186
  • [48] Quantitative Assessment of Drug Efficacy and Emergence of Resistance in Patients with Metastatic Renal Cell Carcinoma Using a Longitudinal Exposure-Tumor Growth Inhibition Model: Apitolisib (Dual PI3K/mTORC1/2 Inhibitor) Versus Everolimus (mTORC1 Inhibitor)
    Moein, Anita
    Jin, Jin Y.
    Wright, Matthew R.
    Wong, Harvey
    JOURNAL OF CLINICAL PHARMACOLOGY, 2024, 64 (09): : 1101 - 1111
  • [49] Free-fatty acid receptor-1 (FFA1/GPR40) promotes papillary RCC proliferation and tumor growth via Src/PI3K/AKT/NF-κB but suppresses migration by inhibition of EGFR, ERK1/2, STAT3 and EMT
    Priyanka F. Karmokar
    Nader H. Moniri
    Cancer Cell International, 23
  • [50] Free-fatty acid receptor-1 (FFA1/GPR40) promotes papillary RCC proliferation and tumor growth via Src/PI3K/AKT/NF-κB but suppresses migration by inhibition of EGFR, ERK1/2, STAT3 and EMT
    Karmokar, Priyanka F. F.
    Moniri, Nader H. H.
    CANCER CELL INTERNATIONAL, 2023, 23 (01)