A new bookmark of the mitotic genome in embryonic stem cells

被引：5
|
作者：
Hsiung, Chris C. -S. [1 ]
Blobel, Gerd A. [1 ]
机构：
[1] Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA
来源：
NATURE CELL BIOLOGY | 2016年 / 18卷 / 11期
关键词：
TRANSCRIPTION FACTORS; CHROMOSOMES; CHROMATIN; PROTEINS; MITOSIS; TARGET; ESRRB;
D O I：
10.1038/ncb3432
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Embryonic stem cells maintain pluripotency through countless mitoses. A recent report shows that the transcription factor Esrrb remains bound to chromatin during mitosis, including at regulatory regions that support pluripotency. Mitotic chromatin occupancy by Esrrb might stabilize the defining transcriptional programmes of embryonic stem cells through cell division.
引用
收藏
页码：1124 / 1125
页数：3
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