A STIMulating journey into optogenetic engineering

被引：3
|
作者：
Ma, Guolin [1 ]
Zhou, Yubin [1 ]
机构：
[1] Texas A&M Univ, Inst Biosci & Technol, Ctr Translat Canc Res, Houston, TX 77030 USA
来源：
CELL CALCIUM | 2020年 / 88卷
基金：
美国国家卫生研究院;
关键词：
Calcium signaling; CRAC channel; Optogenetics; STIM1;
D O I：
10.1016/j.ceca.2020.102197
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Genetically-encoded calcium actuators (GECAs) stemmed from STIM1 have enabled optical activation of endogenous ORAI1 channels in both excitable and non-excitable tissues. These GECAs offer new non-invasive means to probe the structure-function relations of calcium channels and wirelessly control the behavior of awake mice.
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页数：2
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