Helichrysum unicapitatum S.G. Senol, O. Segmen & B. Ozturk (Asteraceae) is described and illustrated from the SW province of Anatolia, Turkey. It grows on crystalline calcareous rocks between Evran Tepe and Karababa Tepe (1800-2300 m), situated within the Denizli Babadag (Cadmus) Mountain Range. Helichrysum compact urn seems to be its closest relative and their affinities are discussed based on morphological data and DNA sequences (nrDNA ITS and ETS).