On-line sample preparation for high throughput reversed-phase LC/MS analysis of combinatorial chemistry libraries

被引：0
|
作者：
Tang, L
Fitch, WL
Smith, P
Tumelty, D
Cao, K
Ferla, SW
机构：
[1] Affymax Res Inst, Palo Alto, CA 94304 USA
[2] LEAP Technol Inc, Carrboro, NC 27510 USA
来源：
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2001年 / 4卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography/mass spectrometry (LC/MS). This approach is particularly helpful for the LC/MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.
引用
收藏
页码：287 / 293
页数：7
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