Off-label uses of rituximab in dermatology

被引:27
|
作者
Carr, David R. [1 ]
Heffernan, Michael P. [1 ]
机构
[1] Wright State Univ, Sch Med, Div Dermatol, Dayton, OH 45408 USA
关键词
biologics; rituximab;
D O I
10.1111/j.1529-8019.2007.00141.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Since its approval in 1997 by the FDA, rituximab has been approved for use in certain B-cell lymphomas and treatment-resistant rheumatoid arthritis. Over the past 10 years, many case reports have indicated rituximab's efficacy in a number of inflammatory conditions in dermatology. This article includes a review of the mechanism of action, dosing, and side effect profile, as well as a review of the current literature on off-label uses of the CD20(+) B-cell antagonist rituximab.
引用
收藏
页码:277 / 287
页数:11
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