Investigation of autoantibody profiles for cerebrospinal fluid biomarker discovery in patients with relapsing-remitting multiple sclerosis

被引：14

作者：

Beyer, Natascha Helena ^{[1
,2
]}

Lueking, Angelika ^{[3
]}

Kowald, Axel ^{[3
]}

Frederiksen, Jette Lautrup ^{[4
]}

Heegaard, Niels H. H. ^{[1
]}

机构：

[1] Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen S, Denmark

[2] Statens Serum Inst, Ctr Biosecur & Biopreparedness, DK-2300 Copenhagen S, Denmark

[3] Protagen AG, D-44227 Dortmund, Germany

[4] Glostrup Univ Hosp, Multiple Sclerosis Clin, Dept Neurol, DK-2600 Glostrup, Denmark

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 242卷 / 1-2期

关键词：

Autoantibody profiling; Biomarker; Cerebrospinal fluid; Multiple sclerosis; ANTIMYELIN BASIC-PROTEIN; OLIGODENDROCYTE GLYCOPROTEIN ANTIBODIES; MONOSYMPTOMATIC OPTIC NEURITIS; MYELIN-ASSOCIATED GLYCOPROTEIN; ALPHA-B-CRYSTALLIN; NEUROFILAMENT LIGHT; PROTEOLIPID PROTEIN; ANTIPHOSPHOLIPID ANTIBODIES; ANTIGENIC CANDIDATES; SERUM AUTOANTIBODIES;

D O I：

10.1016/j.jneuroim.2011.08.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using the UNIarray (R) marker technology platform, cerebrospinal fluid immunoglobulin G reactivities of 15 controls and 17 RRMS patients against human recombinant proteins were investigated. Patient cerebrospinal fluids were oligoclonal band positive and reactivities were compared to that of sex- and age-matched controls. We hereby aimed at the characterization of autoreactivity in patients with RRMS. Differences in auto-reactivities between control and RRMS samples were identified comprising autoantigens identified in this study only and previously reported autoantigens as well. A combination of the 10-15 most significant proteins may be investigated further as autoantigens for diagnostic purposes. Additional investigations may include minimizing the number of proteins used in such diagnostic tests. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：26 / 32

页数：7

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