Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: In vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737

被引：30
|
作者：
Ishitsuka, Kenji [1 ]
Kunami, Naoko [1 ]
Katsuya, Hiroo [1 ]
Nogami, Rumiko [1 ]
Ishikawa, Chie [2 ,3 ]
Yotsumoto, Fusanori [4 ]
Tanji, Hiroe [2 ]
Mori, Naoki [2 ]
Takeshita, Morishige [5 ]
Miyamoto, Shingo [6 ]
Tamura, Kazuo [1 ]
机构：
[1] Fukuoka Univ, Dept Internal Med, Div Med Oncol Hematol & Infect Dis, Fukuoka 8140180, Japan
[2] Univ Ryukyus, Grad Sch Med, Div Mol Virol & Oncol, Nishihara, Okinawa 9030215, Japan
[3] Univ Ryukyus, Transdisciplinary Res Org Subtrop & Isl Studies, Nishihara, Okinawa 9030215, Japan
[4] Fukuoka Univ, Sch Med, Dept Biochem, Fukuoka 8140180, Japan
[5] Fukuoka Univ, Sch Med, Dept Pathol, Fukuoka 8140180, Japan
[6] Fukuoka Univ, Dept Obstet & Gynecol, Fukuoka 8140180, Japan
来源：
CANCER LETTERS | 2012年 / 317卷 / 02期
关键词：
ATLL; Novel treatment; Bcl-2 family proteins; Apoptosis; ABT-737; ACUTE LYMPHOBLASTIC-LEUKEMIA; MULTIPLE-MYELOMA CELLS; BH3 MIMETIC ABT-737; NF-KAPPA-B; CONSTITUTIVE ACTIVATION; DOWN-REGULATION; X-L; APOPTOSIS; LYMPHOMA; SENSITIVITY;
D O I：
10.1016/j.canlet.2011.11.030
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-lymphotropic virus type 1 (HTLV-1). ABT-737, a small molecule inhibitor of Bcl-2, Bcl-X-L, and Bcl-w, significantly induced apoptosis in HTLV-1 infected T-cell lines as well as in fresh ATLL cells, and synergistically enhanced the cytotoxicity and apoptosis induced by conventional cytotoxic drugs. Moreover, ABT-737 significantly inhibited the in vivo tumor growth of an ATLL mouse model. These results suggest that the use of an agent targeting anti-apoptotic bcl-2 family proteins, either alone or in combination with other conventional drugs, represents a novel promising approach for ATLL (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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页码：218 / 225
页数：8
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