Impact of Cyclooxygenase-2 in Breast Cancer

被引：0
|
作者：
Hoellen, Friederike [1 ]
Kelling, Katharina [1 ]
Dittmer, Christine [1 ]
Diedrich, Klaus [1 ]
Friedrich, Michael [2 ]
Thill, Marc [1 ]
机构：
[1] Univ Hosp Schleswig Holstein, Dept Gynecol & Obstet, D-23538 Lubeck, Germany
[2] HELIOS Klinikum Krefeld, Krefeld, Germany
来源：
ANTICANCER RESEARCH | 2011年 / 31卷 / 12期
关键词：
Cyclooxygenase; COX-2; breast cancer; tumor; prostaglandin; carcinogenesis; CARCINOMA IN-SITU; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; MESSENGER-RNA EXPRESSION; PROSTAGLANDIN METABOLIZING ENZYMES; COX-2 INHIBITOR CELECOXIB; VITAMIN-D-RECEPTOR; CELL-LINES; CYCLO-OXYGENASE-2; COX-2; AROMATASE EXPRESSION; OVARIAN-CARCINOMA;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.
引用
收藏
页码：4359 / 4367
页数：9
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