A Quantitative NMR Method for Silyllithium Analysis

被引：1

作者：

Bo, Yingjian ^{[1
]}

Sieburth, Scott McN. ^{[1
]}

机构：

[1] Temple Univ, Dept Chem, 1901 N 13th St, Philadelphia, PA 19122 USA

来源：

SYNLETT | 2017年 / 28卷 / 18期

关键词：

silicon; lithium; lithiation; organometallic reagents; halogens; hydrides; PHENYLDIMETHYLSILYLLITHIUM REAGENT; STEREOSELECTIVE-SYNTHESIS; SUBSTITUTED DISILANES; PRECURSORS; BENZYLLITHIUM; VINYLSILANES; POLYOLS; ACETALS;

D O I：

10.1055/s-0036-1590902

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid and extremely simple method for silyl anion analysis is presented. The progress of silyllithium reagent preparation can be determined by quenching an aliquot with neat chloro(trimethyl) silane, evaporation, dilution with CDCl3, and direct proton NMR analysis. This procedure is fast, simple, and allows for identification and relative quantification of the starting reagent, intermediates, and the silyllithium product.

引用

页码：2449 / 2452

页数：4

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