Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses

被引：66
|
作者：
Liu, Yi [1 ]
Curlin, Marcel E. [1 ]
Diem, Kurt [2 ]
Zhao, Hong [1 ]
Ghosh, Ananta K. [1 ]
Zhu, Haiying [2 ]
Woodward, Amanda S. [2 ]
Maenza, Janine [3 ]
Stevens, Claire E. [3 ]
Stekler, Joanne [3 ]
Collier, Ann C. [3 ]
Genowati, Indira [1 ]
Deng, Wenjie [1 ]
Zioni, Rafael [2 ]
Corey, Lawrence [2 ,3 ,4 ]
Zhu, Tuofu [1 ,2 ]
Mullins, James I. [1 ,2 ,3 ]
机构：
[1] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA
[2] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA
[3] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA
[4] Fred Hutchinson Canc Res Ctr, Dept Program Infect Dis, Seattle, WA 98109 USA
来源：
VIROLOGY | 2008年 / 374卷 / 02期
关键词：
HIV-1; Env sequence length; N-linked glycosylation sites; transmission; primary infection;
D O I：
10.1016/j.virol.2008.01.029
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：229 / 233
页数：5
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