Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer

被引：6
|
作者：
Gelissen, Julia H. [1 ]
Huang, Gloria S. [1 ]
机构：
[1] Yale Univ, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词：
EMT; endometrial cancer; endocrine; estrogen; diabetes; glucose; metformin; ESTROGEN-RECEPTOR-ALPHA; E-CADHERIN; GENE-EXPRESSION; CELLS; GENISTEIN; PROTEIN; PROLIFERATION; PROGRESSION; MIGRATION; CHEMICALS;
D O I：
10.3389/fonc.2022.914405
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The epithelial mesenchymal transition (EMT) is the process by which cancer cells of epithelial origin, including endometrial cancer, acquire a mesenchymal phenotype with enhanced migratory and invasive capacity, to facilitate metastasis. The regulation of EMT is tissue-specific, and in endometrial cancer, endocrine signaling pathways serve as critical regulators of EMT. The intersections of endocrine signaling and EMT highlight potential avenues for therapeutic intervention to target cancer metastasis with the aim of reduced mortality.
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页数：8
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