Behavioral effects of Ginkgo biloba L., Panax ginseng CA Mey. and Gincosan®

被引：14

作者：

Petkov, VD ^{[1
]}

Belcheva, S ^{[1
]}

Petkov, VV ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Physiol, Lab Expt Psychopharmacol, BU-1113 Sofia, Bulgaria

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2003年 / 31卷 / 06期

关键词：

Ginkgo biloba L. (Gk501); Panax ginseng CA Mey. (G115); Gincosan (R) (PHL-00701); learning; memory; cognition-enhancing (Nootropic) drugs; STANDARDIZED EXTRACTS; BRAIN; COMBINATION; PHL-00701; SYSTEM; G115;

D O I：

10.1142/S0192415X03001533

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The behavioral effects of a standardized extract from Panax ginseng roots (G 115), of a standardized extract from Ginkgo biloba leaves (GK501) and of their combination (PHL-00701) (Gincosan((R))) were examined in experiments on rats with undisturbed memory and on rats with experimentally-impaired memory (by alcohol or by muscarinic- and dopamine-receptor antagonists), using methods for active avoidance (shuttle-box) and passive avoidance (step-down and step-through). On multiple administration G115, GK501 and PHL-00701 exerted favorable effects on learning and memory. These effects varied with the dose and administration schedules, with the rat strain and with the behavioral method. Based on earlier results, we discuss the role of changes in brain biogenic amines induced by the extracts in their mechanism of action. The present results allow for ranking G115, GK501 and their combination PHL-00701 (Gincosan((R))) among cognition-enhancing (nootropic) drugs.

引用

页码：841 / 855

页数：15

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